Dysbiosis signature of mycobiota in colon polyp and colorectal cancer
Dysbiosis signature of mycobiota in colon polyp and colorectal cancer
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结肠息肉和结直肠癌中真菌群的失调特征。
DOI：
10.1007/s10096-017-3085-6
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发表时间：
2017-12-01
影响因子：
4.5
通讯作者：
Qin, H.
中科院分区：
文献类型：
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作者：
Gao, R.;Kong, C.;Qin, H.
微生物群是指微生物的菌落，它们存在于所有多细胞生物中。该菌落在其栖息的生物体的生理和疾病中起着重要作用。宿主-微生物群的相互作用受到了很大的关注，但对其在致癌作用中的作用的研究很少。在这项研究中，我们首次对131名受试者（包括息肉和结直肠癌（CRC）患者以及健康对照人群）的粪便真菌生物群（也称为真菌特征）进行了表征。对获得的数据进行分析，以评估真菌的生物多样性和组成。解剖位置和肿瘤分期对真菌菌群的影响也进行了评估。使用斯皮尔曼检验研究真菌之间的相关性。我们观察到结肠息肉和结直肠癌的真菌生态失调，包括息肉患者的多样性减少，子囊菌/担子菌比例增加，机会性真菌毛孢子菌和马拉色菌比例增加，这可能有利于结直肠癌的进展。关于肿瘤阶段的后续分析表明，早期肿瘤的多样性较低，真菌生物群发生显著变化。最后，真菌的相关性显示了社区内的密切关系，并伴随着揭示了显着的结构差异，在每个临床表型。总之，我们的研究揭示了一种独特的真菌生态失调和真菌网络的改变，这可能在息肉和CRC发病机制中发挥重要作用。
Microbiota refers to a colony of microorganisms, and they are found in all multicellular organisms. This colony plays a major role in both the physiology and disease of the organism it inhabits. Much attention has been paid to host-microbiota interactions, but there has been little investigation on its role in carcinogenesis. In this study, we characterized a fecal mycobiota, also known as fungal signature, for the first time with 131 subjects, comprising polyp and colorectal cancer (CRC) patients, as well as a healthy control population. The data obtained were analyzed to assess the biodiversity and composition of the fungi. The impacts of anatomic position and tumor stage on the mycobiota were also evaluated. Correlations between fungi were investigated using the Spearman test. We observed fungal dysbiosis in colon polyps and CRC, including decreased diversity in polyp patients, an increased Ascomycota/Basidiomycota ratio, and an increased proportion of opportunistic fungi Trichosporon and Malassezia, which might favor the progression of CRC. Subsequent analysis with regard to tumor stage demonstrated a lower diversity and significant mycobiota alteration in early-stage tumors. Finally, the fungal correlation showed a close relationship within the community and concomitantly revealed a dramatically structured discrepancy in each clinical phenotype. In conclusion, our study has uncovered a distinct fungal dysbiosis and an alteration in the fungal network, which could play important roles in polyp and CRC pathogenesis.