The potency of blood serum of mares in progressive stages of pregnancy in effecting the sexual maturity of the immature rat
The potency of blood serum of mares in progressive stages of pregnancy in effecting the sexual maturity of the immature rat
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DOI：
10.1152/ajplegacy.1930.93.1.57
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发表时间：
1930-05-01
影响因子：
--
通讯作者：
Hart, GH
中科院分区：
文献类型：
--
作者：
Cole, HH;Hart, GH
对62匹母马的血液进行了诱导未成熟大鼠性成熟的效力试验。非妊娠母马的血清在所有情况下都为阴性，直到怀孕第37天的母马的血清也是阴性的。从第37天到第42天，不同个体的血清首次出现阳性反应的时间不同。在妊娠第43天至第80天，血清对试验动物卵巢大小的影响最为显着。此时，中等剂量使实验动物的卵巢显着增大，并出现广泛的组织学改变。在怀孕后期，对注射血清的反应仅限于子宫和阴道的变化。母马血清中垂体前叶激素的高值期与着床时间呈正相关。作者用相同的不同剂量的血清样本证明了注射量与怀孕特定阶段卵巢中表现出的反应之间的定量关系。妊娠母马血液中存在的垂体性成熟激素可作为诊断妊娠6-7周的一种手段。这种反应一直持续到怀孕的第100天。后期反应的特征是子宫和阴道的改变，很可能是由毛囊引起的。测试是在怀孕222天之后进行的。
The blood of 62 mares was tested for its potency in inducing sexual maturity of immature rats. Serum from non-pregnant mares was negative in all instances as was the serum of mares up to the 37th day of pregnancy. The time of pregnancy at which the serum first gave a positive reaction varied in different individuals from the 37th to the 42nd day. Between the 43rd and 80th day of pregnancy the serum had the most marked effect upon the size of the ovaries of the test animals. At this time medium doses produced marked enlargement and extensive histological alterations of the ovaries of the experimental animals. At later stages of pregnancy the reactions to the injections of the serum were confined to changes in the uterus and vagina. A correlation was observed to exist between the period of high concentration of anterior hypophyseal hormone in the serum and the time of implantation in the mare. The authors were able with the same sample of serum given in varying doses to demonstrate a quantitative relationship between the amount injected and the reaction manifested in the ovary at definite stages of pregnancy. The presence of the anterior hypophyseal sex maturing hormone in the blood of pregnant mares may be used as a means of diagnosing pregnancy of 6-7 weeks'' duration in these animals. This reaction continues until about the 100th day of pregnancy. Later reactions are characterized by changes in the uterus and vagina only and are probably elicited by folliculin. Tests were not made beyond the 222nd day of pregnancy.