Development of an Electromechanical Grade to Assess Human Knee Articular Cartilage Quality
Development of an Electromechanical Grade to Assess Human Knee Articular Cartilage Quality
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DOI：
10.1007/s10439-017-1879-4
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发表时间：
2017-10-01
影响因子：
3.8
通讯作者：
Buschmann, Michael D.
中科院分区：
文献类型：
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作者：
Sim, Sotcheadt;Hadjab, Insaf;Buschmann, Michael D.
需要定量评估关节软骨功能，以帮助临床决策。我们的目标是开发一种新的机电等级来定量评估软骨质量并测试其可靠性。机电性能进行了测量，使用手持机电探针对200人的关节面尸体捐赠者和骨关节炎患者。这些数据被用来创建一个参考机电性能数据库，并比较与视觉关节镜国际软骨修复协会（ICRS）分级的软骨退化。研究了患者特异性和位置特异性特征对机电性能的影响，以构建类似于ICRS等级的连续定量机电等级。通过将其与37个人类关节面的ICRS等级进行比较，评估了这种新等级的可靠性。每个ICRS等级的机电性能不受患者特定特征的影响，但在关节面上存在显著差异。机电性能随ICRS等级线性变化，导致从一个尺度到另一个尺度的简单线性变换。机电分级与ICRS分级密切相关（r = 0.92，p < 0.0001）。此外，机电等级检测到目视未发现的病变。这种新的分级可以通过提供定量和可靠的分级系统来帮助外科医生评估人类膝关节软骨。
Quantitative assessments of articular cartilage function are needed to aid clinical decision making. Our objectives were to develop a new electromechanical grade to assess quantitatively cartilage quality and test its reliability. Electromechanical properties were measured using a hand-held electromechanical probe on 200 human articular surfaces from cadaveric donors and osteoarthritic patients. These data were used to create a reference electromechanical property database and to compare with visual arthroscopic International Cartilage Repair Society (ICRS) grading of cartilage degradation. The effect of patient-specific and location-specific characteristics on electromechanical properties was investigated to construct a continuous and quantitative electromechanical grade analogous to ICRS grade. The reliability of this novel grade was assessed by comparing it with ICRS grades on 37 human articular surfaces. Electromechanical properties were not affected by patient-specific characteristics for each ICRS grade, but were significantly different across the articular surface. Electromechanical properties varied linearly with ICRS grade, leading to a simple linear transformation from one scale to the other. The electromechanical grade correlated strongly with ICRS grade (r = 0.92, p < 0.0001). Additionally, the electromechanical grade detected lesions that were not found visually. This novel grade can assist the surgeon in assessing human knee cartilage by providing a quantitative and reliable grading system.