Low CTLA-4 expression in CD4+ helper T-cells in patients with fulminant type 1 diabetes
Low CTLA-4 expression in CD4+ helper T-cells in patients with fulminant type 1 diabetes
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DOI：
10.1016/j.imlet.2011.05.003
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发表时间：
2011-09-30
影响因子：
4.4
通讯作者：
Hanafusa, Toshiaki
中科院分区：
文献类型：
--
作者：
Haseda, Fumitaka;Imagawa, Akihisa;Hanafusa, Toshiaki
暴发性1型糖尿病是1型糖尿病的一种新亚型，其特征是胰岛素缺乏性高血糖症的显著突然发作。加速的免疫反应被认为是这种疾病中β细胞明显快速损失的原因，但确切的机制尚未阐明。检测了16例暴发型1型糖尿病患者、14例1A型糖尿病患者、10例2型糖尿病患者和20例正常对照者CD 4（+）辅助性T细胞中细胞毒性T淋巴细胞抗原4（CTLA-4）的表达。暴发型1型糖尿病患者CD 4（+）辅助性T细胞CTLA-4表达较其他3组显著降低（P < 0.05）。在CD 4（+）CD 25（高）T细胞和CD 4（+）CD 25（-）T细胞中也观察到低CTLA-4表达。CD 4（+）CD 25（-）T细胞增殖与CTLA-4水平呈显著负相关。CTLA-4在CD 4（+）辅助性T细胞中的细胞内表达与两种CTLA-4多态性无关。总之，CTLA-4在CD 4（+）辅助性T细胞中的表达在暴发性1型糖尿病患者中较低。(C)2011 Elsevier B. V.保留所有权利。
Fulminant type 1 diabetes is a novel subtype of type I diabetes characterized by a remarkably abrupt onset of insulin-deficient hyperglycemia. An accelerated immune reaction has been suggested as the cause of markedly rapid beta cell loss in this disease, but the precise mechanism has not been clarified. We analyzed the expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) in CD4(+) helper T-cells in 16 patients with fulminant type 1 diabetes, 14 patients with type 1A diabetes, 10 patients with type 2 diabetes and 20 normal control subjects. There was a significant reduction in CTLA-4 expression in CD4(+) helper T-cells from patients with fulminant type 1 diabetes (P < 0.05) compared with the other three groups. Low CTLA-4 expression was also observed in both CD4(+)CD25(high) T-cells and CD4(+)CD25(-) T-cells. There was a significant negative correlation between the proliferation of CD4(+)CD25(-) T-cells and the levels of CTLA-4. Intracellular expression of CTLA-4 in CD4(+) helper T-cells was not correlated with two CTLA-4 polymorphisms. In conclusion, the expression of CTLA-4 in CD4(+) helper T-cells was low in patients with fulminant type 1 diabetes. (C) 2011 Elsevier B.V. All rights reserved.