Large Scale Protein Modeling and Model Repository
Large Scale Protein Modeling and Model Repository
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发表时间：
1997-06
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通讯作者：
M. Peitsch
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作者：
M. Peitsch
基于知识的蛋白质分子模型已被证明在许多情况下是有用的，包括诱变实验的合理设计，但它通常受到昂贵的计算机硬件和软件的可用性的限制。为了克服这些限制，我们开发了SWISS-MODEL服务器，用于自动化的基于知识的蛋白质建模。SWISS-MODEL服务器使用布鲁克海文蛋白质数据库作为结构信息的来源，并自动生成与已知3d结构的至少一种蛋白质具有显着相似性的序列的蛋白质模型。我们现在使用服务器的软件框架来生成大量的蛋白质模型集合。为了存储这些模型，我们建立了SWISS-MODEL Repository，这是一个由理论方法生成的蛋白质模型的新数据库。该存储库通过ExPASy worldwide Web服务器（URL为http:(/)/www.expasy.ch）直接与SWISS-PROT和其他数据库集成。
Knowledge-based molecular modelling of proteins has proven useful in many instances including the rational design of mutagenesis experiments, but it has been generally limited by the availability of expensive computer hardware and software. To overcome these limitations, we have developed the SWISS-MODEL server for automated knowledge-based protein modelling. The SWISS-MODEL server uses the Brookhaven Protein Data Bank as a source of structural information and automatically generates protein models for sequences which share significant similarities with at least one protein of known 3D-structure. We now use the software framework of the server to generate large collections of protein models. To store these models, we have established the SWISS-MODEL Repository, a new database for protein models generated by theoretical approaches. This repository is directly integrated with SWISS-PROT and other databases through the ExPASy World-Wide Web server (URL is http:(/)/www.expasy.ch).