Neuropeptide Y impairs the acquisition of conditioned defeat in Syrian hamsters.
Neuropeptide Y impairs the acquisition of conditioned defeat in Syrian hamsters.
复制标题
神经肽 Y 会损害叙利亚仓鼠条件性失败的获得。
DOI：
10.1016/j.neulet.2018.09.049
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发表时间：
2019
影响因子：
2.5
通讯作者：
Markham,ChrisM
中科院分区：
文献类型：
--
作者：
Lacey,Tiara;Sweeting,Josiah;Kingston,Rody;Smith,Michael;Markham,ChrisM
最近的证据表明，神经肽Y（NPY）可能是一种有效的抗焦虑剂，也是一种弹性因子，可以使大脑免受压力的影响。然而，这些研究中的大多数都利用了身体压力，如休克或约束。在本研究中，我们使用一个基于行为学的模型在叙利亚仓鼠（Mesocricetus auratus）称为条件性失败（CD），以调查是否NPY可以改善社会失败压力的影响。在CD模型中，一只雄性叙利亚仓鼠在社交上被一只更大、更具攻击性的同类打败。随后，当与一个较小的，非侵略性的入侵者（NAI）在自己的家笼配对时，其行为库发生变化，包括减少侵略和化学感觉（社会）调查，以及随之而来的顺从行为增加。在实验1中，仓鼠脑室内（icv）与NPY之前，社会失败，24小时后，仓鼠暴露于NAI。结果表明，神经肽Y显着减少顺从/防御行为在社会上失败的仓鼠相比，控制动物。在实验2中，我们研究了这种效应是否由NPY Y1受体介导。受试者首先接受Y1受体拮抗剂BIBF 3226或溶剂预处理，然后接受NPY，然后接受社交失败。在24小时后用NAI测试时，与对照相比，用BIBF 3226预处理未能阻断NPY效应。这些结果表明，神经肽Y可能作为一个重要的弹性因素，在社会上失败的仓鼠，但这些影响是不介导的Y1受体。
Recent evidence indicates that Neuropeptide Y (NPY) may function as a potent anxiolytic as well as a resilience factor that can insulate the brain from the effects of stress. However, most of these studies have utilized physical stressors such as shock or restraint. In the present study, we use an ethologically-based model in Syrian hamsters (Mesocricetus auratus)called Conditioned Defeat (CD) to investigate whether NPY can ameliorate the effect of social defeat stress. In the CD model, a male Syrian hamster is socially defeated by a larger, more aggressive conspecific. Subsequently, when paired with a smaller, non-aggressive intruder (NAI) in its own home cage, changes in its behavioral repertoire occur, including a reduction in aggression and chemosensory (social) investigation, and a concomitant increase in submissive behaviors. In Experiment 1, hamsters were infused intracerebroventricularly (icv) with NPY prior to social defeat, and 24-hours later, hamsters were exposed to a NAI. Results indicate that NPY significantly reduced submissive/defensive behaviors in socially defeated hamsters compared to control animals. In Experiment 2, we examined whether this effect was mediated by the NPY Y1 receptor. Subjects were first pre-treated with the Y1 receptor antagonist BIBP 3226 or vehicle, followed by NPY and then socially defeated. Upon testing with a NAI 24-hours later, pretreatment with BIBP 3226 failed to block the NPY effect compared to controls. These results demonstrate that NPY may function as an important resilience factor in socially defeated hamsters, but that these effects are not mediated by the Y1 receptor.