ETHANOL SENSITIVITY AND CONSUMPTION IN F(2) HYBRID CROSSES OF ANT AND AT RATS
ETHANOL SENSITIVITY AND CONSUMPTION IN F(2) HYBRID CROSSES OF ANT AND AT RATS
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DOI：
10.1016/0741-8329(93)90030-r
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发表时间：
1993-09-01
期刊：
影响因子：
2.3
通讯作者：
KORPI, ER
中科院分区：
文献类型：
--
作者：
SARVIHARJU, M;KORPI, ER
在10%（v/v）乙醇溶液和水之间的自由选择试验中，对中等乙醇剂量的运动损伤效应高度敏感的ANT大鼠自愿饮用较少的乙醇，而乙醇不敏感的AT大鼠，这表明乙醇饮用受初始乙醇敏感性影响的可能性。然而，在F2杂交的ANT和AT大鼠，自愿饮酒乙醇并没有相关的敏感性，在倾斜平面试验中乙醇的运动损伤的影响。因此，初始乙醇敏感性似乎不是解释自愿饮酒变化的主要因素。
ANT rats that are highly sensitive to the motor-impairing effects of moderate ethanol doses voluntarily drink less ethanol in a free-choice test between 10% (v/v) ethanol solution and water than the ethanol-insensitive AT rats, suggesting the possibility that ethanol drinking is affected by initial ethanol sensitivity. However, in the F2 hybrid crosses of ANT and AT rats, voluntary ethanol drinking did not correlate with sensitivity to the motor-impairing effects of ethanol in the tilting plane test. Therefore, initial ethanol sensitivity does not appear to be a major factor in explaining variation in voluntary ethanol drinking.