Pointing in the right direction: new developments in the field of planar cell polarity.
Pointing in the right direction: new developments in the field of planar cell polarity.
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DOI：
10.1038/nrg2956
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Axelrod JD
中科院分区：
文献类型：
--
作者：
Bayly R;Axelrod JD
平面细胞极性（PCP）在一系列涉及集体细胞运动和组织的发育过程中被观察到，其破坏可导致严重的发育缺陷。最近对苍蝇和脊椎动物的研究已经确定了五氯苯酚的新功能、新的信号成分，并提出了新的机制模型。然而，尽管取得了这一进展，寻求简化理解的原则仍在继续，重要的机械不确定性仍然构成了巨大的挑战。
Planar Cell Polarity (PCP) is observed in an array of developmental processes involving collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in both flies and vertebrates have identified new functions for PCP, new signaling components, and proposed new mechanistic models. However, despite this progress, the search for simplifying principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.