Near-future CO2 levels impair the olfactory system of a marine fish
Near-future CO2 levels impair the olfactory system of a marine fish
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DOI：
10.1038/s41558-018-0224-8
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发表时间：
2018-08-01
影响因子：
30.7
通讯作者：
Wilson, Rod W.
中科院分区：
文献类型：
--
作者：
Porteus, Cosima S.;Hubbard, Peter C.;Wilson, Rod W.
海洋鱼类的生存，暴露在不久的将来升高的二氧化碳水平的威胁，他们改变了对感官线索的反应。在这里，我们展示了嗅觉系统的生理和分子机制，有助于解释二氧化碳浓度升高时行为的改变。我们将联合收割机电生理学测量和转录组学与行为实验相结合，研究二氧化碳浓度升高如何影响欧洲鲈鱼（Dicentrarchus labrax）的嗅觉系统。当暴露于高浓度的二氧化碳（约1,000 mu atm）时，与目前的二氧化碳水平（约400 mu atm）相比，鱼类必须离气味源近42%才能检测到，这降低了它们检测食物或捕食者的机会。嗅觉受损与参与突触强度、细胞兴奋性和嗅觉系统布线的基因转录的抑制相关，这些基因响应于持续暴露于升高的CO2水平。我们的研究结果补充了先前提出的γ-氨基丁酸受体受损，并表明嗅觉系统和中枢脑功能都受到CO2水平升高的影响。
Survival of marine fishes that are exposed to elevated near-future CO2 levels is threatened by their altered responses to sensory cues. Here we demonstrate a physiological and molecular mechanism in the olfactory system that helps to explain altered behaviour under elevated CO2. We combine electrophysiology measurements and transcriptomics with behavioural experiments to investigate how elevated CO2 affects the olfactory system of European sea bass (Dicentrarchus labrax). When exposed to elevated CO2 (approximately 1,000 mu atm), fish must be up to 42% closer to an odour source for detection, compared with current CO2 levels (around 400 mu atm), decreasing their chances of detecting food or predators. Compromised olfaction correlated with the suppression of the transcription of genes involved in synaptic strength, cell excitability and wiring of the olfactory system in response to sustained exposure to elevated CO2 levels. Our findings complement the previously proposed impairment of gamma-aminobutyric acid receptors, and indicate that both the olfactory system and central brain function are compromised by elevated CO2 levels.