Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia.
Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia.
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DOI：
10.1002/path.2714
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发表时间：
2010-07
影响因子：
7.3
通讯作者：
Janz, Siegfried
中科院分区：
文献类型：
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作者：
de Jong, Daphne;Janz, Siegfried
小鼠模型可为人类疾病的基础和应用研究提供重要工具。一个理想的肿瘤模型应该复制人类恶性肿瘤的表型和分子特征以及典型的生理效应和传播模式。NSF.V+小鼠中间变性浆细胞瘤（APCT）的组织病理学和分子遗传学特征为实现特定淋巴瘤亚型的这一目标提供了一个例子。首先，它表明，像人类的浆细胞肿瘤一样，小鼠中的浆细胞肿瘤作为不同的亚型发生。其次，它表明小鼠APCT与可能的人类肿瘤对应物表现出惊人的相似之处，迫切需要良好的小鼠从头肿瘤发展模型：IgM+多发性骨髓瘤和Waldenström巨球蛋白血症。第三，它强烈表明，插入体细胞诱变，无论是鼠白血病病毒或致癌转座子，将是一种有效的实验方法，以加速小鼠成熟B细胞和浆细胞的恶性转化，从而标记和揭示癌症驱动基因，可能是非常相关的肿瘤的起始和发展淋巴瘤。
Mouse models may provide an important tool for basic and applied research on human diseases. An ideal tumour model should replicate the phenotypic and molecular characteristics of human malignancy as well as the typical physiological effects and dissemination patterns. The histopathological and molecular genetic characterization of anaplastic plasmacytoma (APCT) in strain NSF.V+ mice provides an example to achieve this goal for a specific lymphoma subtype. Firstly, it demonstrates that, like plasma-cell neoplasms in humans, those in mice occur as distinct subtypes. Secondly, it shows that mouse APCT exhibits striking parallels to possible human tumour counterparts for which good mouse models of de novo tumour development are sorely needed: IgM+ multiple myeloma and Waldenström’s macroglobulinaemia. Thirdly, it strongly suggests that insertional somatic mutagenesis, by either a murine leukaemia virus or an oncogenic transposon, would be an effective experimental approach to accelerating malignant transformation of mature B cells and plasma cells in mice and, thereby, tagging and uncovering cancer driver genes that may be of great relevance for the tumour initiation and progression in lymphoma.
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FAS FAS配体相互作用有缺陷的小鼠中静脉瘤肿瘤的自发发展。
影响因子：
15.3
作者：
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通讯作者：
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影响因子：
2.7
作者：
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影响因子：
6
作者：
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通讯作者：
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
11.4
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