Heart disease risk factors and hormone use in postmenopausal women.
Heart disease risk factors and hormone use in postmenopausal women.
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绝经后妇女的心脏病危险因素和激素使用。
DOI：
10.1001/jama.1979.03290460031015
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
M. Criqui
中科院分区：
文献类型：
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作者：
E. Barrett;W. Brown;J. Turner;M. Austin;M. Criqui
研究了1,496名年龄在55至74岁之间的妇女在绝经后雌激素存在或不存在的情况下心脏病危险因素的分布。目前使用激素的报告为39%。在所有年龄段，激素使用者都比不使用者显着苗条。在调整肥胖的影响后，激素使用者的血浆胆固醇平均水平显著低于非使用者，血浆甘油三酯平均水平显著高于非使用者。激素使用者的血压和空腹血糖浓度往往较低，尽管在所有年龄组中差异无统计学意义。本文讨论了这些观察结果对心血管疾病死亡率的理论意义，并将其与绝经后使用雌激素的癌症风险进行了对比。
A population of 1,496 women aged 55 to 74 years was studied for the distribution of heart disease risk factors in the presence or absence of postmenopausal estrogens. Current hormone use was reported by 39%. Hormone users were significantly slimmer than nonusers at all ages. After adjustment for the effect of obesity, hormone users had significantly lower mean levels of plasma cholesterol and higher mean levels of plasma triglycerides than nonusers. Blood pressure and fasting plasma glucose concentration tended to be lower among hormone users, although the differences were not statistically significant in all age groups. This article discusses the theoretical implications of these observations for cardiovascular disease mortality and contrasts them with the cancer risk of postmenopausal estrogen use.