Incidence and survival of mesothelioma in Osaka, Japan
Incidence and survival of mesothelioma in Osaka, Japan
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DOI：
10.1093/jjco/hyl018
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发表时间：
2006-04-01
影响因子：
2.4
通讯作者：
Oshima, Akira
中科院分区：
文献类型：
--
作者：
Kanazawa, Naoko;Ioka, Akiko;Oshima, Akira
背景：死亡率统计显示间皮瘤死亡人数迅速增加。然而，从未进行过基于人群的发病率和生存率研究。间皮瘤在大坂的发病率的时间趋势和区域差异进行了检查，连同他们的5年survival.Methods：间皮瘤的个人数据，从大坂癌症登记处在1966年至2001年期间检索。从1975年到2001年，每3年计算一次年发病率，年龄标准化率采用1985年的日本模型人群计算。标准化的发病率也计算了特定年龄的人口数量的每个市和相应的年龄特定发病率间皮瘤在大坂府在1981年至2001年期间。生存分析采用Kaplan-Meier法，以1975- 1997年新报告的间皮瘤病例为基础。结果：近几十年来，大坂市男性和女性间皮瘤发病率均呈快速上升趋势。标准化发病率的地理差异在大坂府是显着的。结果显示恶性间皮瘤的生存率很低（5年生存率和中位生存时间：男性为5.1%和6个月，女性为10.2%和5个月）。还提出了发病率的地理差异。患者的5年生存率很低。
Background: Mortality statistics show rapid increase in the number of deaths from mesothelioma. However, population-based study of the incidence and the survival has never been conduced. Time-trends and regional differences in the incidence of mesothelioma in Osaka were examined together with their 5-year survival.Methods: Individual data for mesothelioma were retrieved from Osaka Cancer Registry during the period 1966-2001. Annual incidence rates were calculated for every 3 years from 1975 to 2001, and age-standardized rates were calculated with the Japanese model population of 1985. Standardized incidence ratios were also calculated by age-specific number of population of each municipality and the corresponding age-specific incidence rates of mesothelioma in Osaka Prefecture during the period 1981-2001. The survival analysis was performed with the Kaplan-Meier method, based on the newly reported cases diagnosed during the period 1975-1997.Results: Incidence rates of mesothelioma have increased rapidly both among males and females in Osaka during the past few decades. Geographical differences in the standardized incidence ratios were found to be remarkable in Osaka Prefecture. The result shows that the survival of malignant mesothelioma was very poor (5-year survival and median survival time: 5.1% and 6 months for males, 10.2% and 5 months for females).Conclusions: Incidence of mesothelioma has increased remarkably in Osaka, Japan, during past few decades. Geographical variations in the incidence were also suggested. Five-year survival of the patients was very poor.