Identification of Ecl Family Genes That Extend Chronological Lifespan in Fission Yeast
Identification of Ecl Family Genes That Extend Chronological Lifespan in Fission Yeast
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DOI：
10.1271/bbb.80804
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发表时间：
2009-04-01
影响因子：
1.6
通讯作者：
Aiba, Hirofumi
中科院分区：
文献类型：
--
作者：
Ohtsuka, Hokuto;Ogawa, Yuki;Aiba, Hirofumi
在分裂酵母中，我们发现了两个基因ecl2（+）和ecl3（+），这两个基因与ecl1（+）是旁系同源的，可以延长生物的寿命。ecl2（+）和ecl3（+）在过度表达为ecl1（+）时都延长了时间寿命。ECL2（+）和ECL3（+）分别编码84和89个氨基酸的多肽，它们在当前的数据库中没有注释。Ecl 2蛋白主要定位于细胞核中，如Ecl 1。这些结果表明，ecl1（+），ecl2（+）和ecl3（+）在时间寿命的调节中具有重叠的功能。
In fission yeast, we identified two genes, named ecl2(+) and ecl3(+), that are paralogous to ecl1(+), which extends the chronological lifespan. Both ecl2(+) and ecl3(+) extend the chronological lifespan when overexpressed as ecl1(+). ecl2(+) and ecl3(+) encode 84- and 89-amino acid polypeptides respectively that are not annotated in the current database. The Ecl2 protein is localized mainly in the nucleus, as Ecl1. These results suggest that ecl1(+), ecl2(+), and ecl3(+) have overlapping functions in the regulation of chronological lifespan.