Imparting magnetic dipole heterogeneity to internalized iron oxide nanoparticles for microorganism swarm control
Imparting magnetic dipole heterogeneity to internalized iron oxide nanoparticles for microorganism swarm control
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DOI：
10.1007/s11051-014-2746-y
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发表时间：
2015-03-17
影响因子：
2.5
通讯作者：
Kim, Min Jun
中科院分区：
文献类型：
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作者：
Kim, Paul Seung Soo;Becker, Aaron;Kim, Min Jun
梨形四膜虫是一种单细胞真核生物，它可以被修改以响应磁场，这种响应称为趋磁性。自然地，这种微生物不能对磁场做出反应，但在使用氧化铁纳米颗粒进行修饰后，细胞被磁化并表现出恒定的磁偶极子强度。在实验中，使用二维近似亥姆霍兹线圈系统向细胞施加旋转场。利用旋转磁场，我们描述了离散细胞的群体游泳，这是由几个因素的影响。这些领域下的细胞的行为进行了详细解释。在移除了场之后，观察到相对直的游泳。我们还在细胞群体中产生增加的异质性，以提高群体的可控性，这是在细胞模型中探索的。通过利用这种直线游泳行为，我们提出了一种方法来控制离散细胞利用一个单一的全球磁输入。这种群体控制方法的成功实施将使微型机器人团队能够执行单个微型机器人不可能完成的各种体外微型任务，例如推动物体或同时对离散实体进行显微操作。
Tetrahymena pyriformis is a single cell eukaryote that can be modified to respond to magnetic fields, a response called magnetotaxis. Naturally, this microorganism cannot respond to magnetic fields, but after modification using iron oxide nanoparticles, cells are magnetized and exhibit a constant magnetic dipole strength. In experiments, a rotating field is applied to cells using a two-dimensional approximate Helmholtz coil system. Using rotating magnetic fields, we characterize discrete cells' swarm swimming which is affected by several factors. The behavior of the cells under these fields is explained in detail. After the field is removed, relatively straight swimming is observed. We also generate increased heterogeneity within a population of cells to improve controllability of a swarm, which is explored in a cell model. By exploiting this straight swimming behavior, we propose a method to control discrete cells utilizing a single global magnetic input. Successful implementation of this swarm control method would enable teams of microrobots to perform a variety of in vitro microscale tasks impossible for single microrobots, such as pushing objects or simultaneous micromanipulation of discrete entities.