CALCIUM-BINDING PROTEIN DISTRIBUTION IN THE RAT-BRAIN
CALCIUM-BINDING PROTEIN DISTRIBUTION IN THE RAT-BRAIN
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DOI：
10.1016/0006-8993(82)90526-1
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
PARKES, CO
中科院分区：
文献类型：
--
作者：
BAIMBRIDGE, KG;MILLER, JJ;PARKES, CO
The distribution in the rat brain of a protein with properties similar to vitamin D-dependent Ca binding protein (CaBP) was measured using a radioimmunoassay developed for mammalian brain CaBP. The cerebellum contained very high levels of CaBP in agreement with reports of CaBP distribution in the chick brain. The protein was distributed in large and unequal concentrations in different regions of the brain. Microdissection of the hippocampus revealed that, within a particular region, CaBP can have a marked differential distribution, suggesting that it is found in specific cell types. The significance of this protein is discussed in relation to the important functions of Ca in the CNS with particular emphasis being placed on the possible role of CaBP as an intraneuronal Ca2+ buffering system.
