Noncompetitive expansion of cytotoxic T lymphocytes specific for different antigens during bacterial infection.
Noncompetitive expansion of cytotoxic T lymphocytes specific for different antigens during bacterial infection.
复制标题
在细菌感染期间，针对不同抗原的细胞毒性 T 淋巴细胞的非竞争性扩增。
DOI：
10.1128/iai.67.3.1303-1309.1999
复制
发表时间：
1999
影响因子：
3.1
通讯作者：
Pamer,EG
中科院分区：
文献类型：
--
作者：
Vijh,S;Pilip,IM;Pamer,EG
Listeria monocytogenesis an intracellular bacterium that elicits complex cytotoxic T-lymphocyte (CTL) responses in infected mice. The responses of CTL populations that differ in antigen specificity range in magnitude from large, dominant responses to small, subdominant responses. To test the hypothesis that dominant T-cell responses inhibit subdominant responses, we eliminated the two dominant epitopes ofL. monocytogenesby anchor residue mutagenesis and measured the T-cell responses to the remaining subdominant epitopes. Surprisingly, the loss of dominant T-cell responses did not enhance subdominant responses. While mice immunized with bacteria lacking dominant epitopes developedL. monocytogenes-specific immunity, their ability to respond to dominant epitopes upon rechallenge with wild-type bacteria was markedly diminished. Recall responses in mice immunized with wild-type or epitope-deficientL. monocytogenesshowed that antigen presentation during recall infection is sufficient for activating memory cells yet insufficient for optimal priming of naive T lymphocytes. Our findings suggest that T-cell priming to different epitopes duringL. monocytogenesinfection is not competitive. Rather, T-cell populations specific for different antigens but the same pathogen expand independently.
