Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect
Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect
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DOI：
10.1053/jhep.2003.50427
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发表时间：
2003-10-01
期刊：
影响因子：
13.5
通讯作者：
Davis, GL
中科院分区：
文献类型：
--
作者：
Nelson, DR;Tu, ZK;Davis, GL
Th1和Th2细胞因子产生的不平衡与HCV的疾病进展有关。我们的目的是确定给药IL-10对hcv相关肝病患者的影响。30例抗病毒治疗失败的晚期纤维化患者参加了为期12个月的治疗方案，每日或每周给予SQ IL-10 3次。治疗前后分别行肝活检。收集血清和PBMC进行HCV RNA、ALT和功能性t细胞分析。IL-10导致血清ALT显著改善(平均ALT：第0天= 142 +/- 17 vs.第12个月= 75 +/- 10
An imbalance in Th1 and Th2 cytokine production is implicated in disease progression of HCV. Our aim was to determine the effect of IL-10 administration in patients with HCV-related liver disease. Thirty patients with advanced fibrosis who had failed antiviral therapy were enrolled in a 12-month treatment regimen with SQ IL-10 given daily or thrice weekly. Liver biopsies were performed before and after therapy. Serum and PBMC were collected for HCV RNA, ALT, and functional T-cell analysis. IL-10 led to significant improvement in serum ALT (mean ALT: day 0 = 142 +/- 17 vs. month 12 = 75 +/- 10; P