Two simple, reliable and valid tests of proximal muscle function, and their application to the management of idiopathic inflammatory myositis
Two simple, reliable and valid tests of proximal muscle function, and their application to the management of idiopathic inflammatory myositis
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DOI：
10.1093/rheumatology/kel017
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发表时间：
2006-07-01
期刊：
影响因子：
5.5
通讯作者：
Kiely, P. D. W.
中科院分区：
文献类型：
--
作者：
Agarwal, S.;Kiely, P. D. W.
Objective.目的：建立客观、等张、可靠、有效的上肢（UL）和下肢（LL）近端肌肉功能测试方法，用于特发性炎症性肌炎（IIM）的治疗。设计了“1 kg手臂提升”测试来评估UL功能，并使用“30 s椅子站立”测试来评估LL功能。在30名对照受试者中进行测试，以确定短（24小时）和长（2周）间隔的重测信度。在2年内对32名IIM患者进行了评估。结果。在对照组中，两个测试都显示出良好的重测信度;两个时间间隔内两个测试的斯皮尔曼相关性> 0.8。32例IIM患者中有24例在平均20.7个月的时间内保持缓解，在此期间，每个患者的平均评分中，“1 kg手臂提升”测试的评分变化< 5，“30 s椅子站立”测试的评分变化< 3。8名患者复发，每例患者的平均缓解评分中，“1 kg手臂提升”测试的评分下降> 5，“30 s椅子站立”测试的评分下降> 3。UL和LL评分均与血清肌酐激酶呈负相关。近端肌肉功能的两个等张试验。他们表现出良好的重测信度和IIM证明结构效度。这两种测试都能对疾病活动的变化做出反应，提供了比现有肌肉功能测试更好的生理和实用优势，适用于临床实践。
Objective. To develop objective, isotonic, reliable and valid tests of upper (UL) and lower (LL) limb proximal muscle function for use in the management of idiopathic inflammatory myositis (IIM).Methods. The '1 kg arm lift' test was devised to assess UL function and the '30 s chair stand' test was used for LL function. The tests were performed in 30 control subjects to determine short (24 h) and long (2 week) interval test-retest reliability. Thirty-two patients with IIM were assessed over a period of 2 yr.Results. In the control group both tests showed excellent test-retest reliability; Spearman correlation > 0.8 for both tests over both time intervals. Twenty-four of the 32 IIM patients remained in remission over a mean period of 20.7 months throughout which scores varied by < 5 for the '1 kg arm lift' test and < 3 for the '30 s chair stand' test from each patient's mean score. Eight patients relapsed with scores falling by > 5 for the '1 kg arm lift' test and by > 3 for the '30 s chair stand' test from the mean remission score in each case. Both UL and LL scores correlated inversely with serum creatinine kinase.Conclusion. Two isotonic tests of proximal muscle function are described. They exhibit excellent test-retest reliability and demonstrate construct validity in IIM. Both tests are responsive to changes in disease activity, offer physiological and practical advantages over existing tests of muscle function and are suitable for use in clinical practice.