PREVALENCE AND RISK-FACTORS OF DIABETIC-RETINOPATHY IN NON-HISPANIC WHITES AND HISPANICS WITH NIDDM - SAN-LUIS VALLEY DIABETES STUDY
PREVALENCE AND RISK-FACTORS OF DIABETIC-RETINOPATHY IN NON-HISPANIC WHITES AND HISPANICS WITH NIDDM - SAN-LUIS VALLEY DIABETES STUDY
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DOI：
10.2337/diabetes.38.10.1231
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发表时间：
1989-10-01
期刊：
影响因子：
7.7
通讯作者：
BAXTER, J
中科院分区：
文献类型：
--
作者：
HAMMAN, RF;MAYER, EJ;BAXTER, J
糖尿病视网膜病变（DR）是美国成年人失明的主要原因。因为光凝可使严重DR致盲的发生率降低约1%。50%，重要的是确定耐药风险增加的人群，以便能够完成适当的治疗。使用糖尿病风险增加的人群可以确定并发症风险增加的人群。圣安东尼奥心脏研究最近的一份报告显示，墨西哥裔美国人比非西班牙裔白人患严重DR的风险更大。为了比较科罗拉多州南部非西班牙裔和西班牙裔之间的DR患病率，279名非胰岛素依赖型糖尿病（NIDDM）患者被确定，视网膜照片确定视网膜病变的存在和严重程度。用较差的眼对每位患者的DR严重程度进行分类。90%的受试者（166名西班牙裔和85名非西班牙裔白人）按视网膜病变程度分类。经持续时间调整后的DR患病率在西班牙裔中为41.8%，在非西班牙裔白人中为54.1%。严重DR（增生前和增生）发生在18.5%的西班牙裔和21.3%的非西班牙裔白人中。任何DR的优势比，将西班牙裔与非西班牙裔白人进行比较，经其他危险因素调整后为0.40（95%可信区间= 0.21,0.76）。存在视网膜病变的其他危险因素包括使用外源性胰岛素、糖尿病持续时间延长、诊断时年龄较小、糖化血红蛋白水平升高和收缩压升高。这些数据表明，与非西班牙裔白人相比，科罗拉多州的西班牙裔人患糖尿病视网膜病变的风险可能会降低。
Diabetic retinopathy (DR) is the leading cause of blindness in adults in the United States. Because photocoagulation can reduce the incidence of blindness from severe DR by .apprx. 50%, it is important to identify people at increased risk for DR so that appropriate treatment can be accomplished. Use of populations at increased risk for diabetes may identify groups at increased risk for complications. A recent report from the San Antonio Heart Study showed that Mexican Americans were at greater risk for severe DR than non-Hispanic Whites. To compare the prevalence of DR between non-Hispanics and Hispanics in southern Colorado, 279 people with non-insulin-dependent diabetes mellitus (NIDDM) were identified, and retinal photographs identified the presence and severity of retinopathy. The worse eye was used to classify the severity of DR for each patient. Ninety percent of the subjects (166 Hispanics and 85 non-Hispanic Whites) were classified by retinopathy level. The duration-adjusted prevalence of any DR was 41.8% in Hispanics and 54.1% in non-Hispanic Whites. Severe DR (preproliferative and proliferative) occurred in 18.5% of the Hispanics and in 21.3% of the non-Hispanic Whites. The odds ratio for any DR, comparing Hispanics with non-Hispanic Whites adjusted for other risk factors, was 0.40 (95% confidence interval = 0.21, 0.76). Other risk factors for the presence of any retinopathy included use of exogenous insulin, increased duration of diabetes, younger age at diagnosis, increased glycosylated hemoglobin level, and increased systolic blood pressure. These data suggest that, compared with non-Hispanic Whites, Hispanics in Colorado may be at decreased risk for diabetic retinopathy.