Exposure to environmental complexity promotes recovery of cognitive function after traumatic brain injury
Exposure to environmental complexity promotes recovery of cognitive function after traumatic brain injury
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DOI：
10.1089/neu.1996.13.41
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发表时间：
1996-01-01
影响因子：
4.2
通讯作者：
Lyeth, BG
中科院分区：
文献类型：
--
作者：
Hamm, RJ;Temple, MD;Lyeth, BG
本研究旨在确定创伤性脑损伤（TBI）后暴露于复杂环境是否会促进认知功能的恢复。致伤后立即将损伤/复合组（n = 8）和假损伤/复合组（n = 7）置于复合环境中。复杂的环境是一个89 x 89厘米的围栏，里面有不同类型的床上用品和提供运动、嗅觉、触觉和视觉刺激的物体。将损伤/标准（n = 8）和假手术/标准（n = 8）组返回动物饲养所，在那里它们被单独饲养在标准金属丝网笼（24 x 20 x 18 cm）中。在第11-15天（损伤后），评估Morris水迷宫中的表现。对到达目标平台的潜伏期的分析表明，在复杂环境中恢复的受伤动物的表现显著优于在标准环境中恢复的受伤动物（p < 0.01）。事实上，在复杂环境中受伤的动物表现得和假受伤组一样好。受伤大鼠在丰富的环境中恢复的性能改善发生在没有环境诱导的脑重量变化。这些结果表明，暴露于环境复杂性增强TBI后认知功能的恢复。
This study was designed to determine whether exposure to a complex environment after traumatic brain injury (TBI) would promote the recovery of cognitive function. Rats were injured at a moderate level of fluid percussion injury (2.1 atm) or were prepared for injury but were not injured (sham injury), Immediately after the injury or sham injury, the injured/complex (n = 8) and the sham/complex (n = 7) groups were placed into a complex environment. The complex environment was a 89 x 89-cm enclosure with different types of bedding and objects that provided motor, ol-factory, tactile, and visual stimulation. The injured/standard (n = 8) and the sham/standard (n = 8) groups were returned to the animal vivarium where they were housed individually in standard wire mesh cages (24 x 20 x 18 cm). On days 11-15 (postinjury), performance in the Morris water maze was assessed. Analysis of the latency to reach the goal platform indicated that injured animals recuperating in the complex environment performed significantly better than injured animals recovering in the standard environment (p < 0.01). In fact, injured animals in the complex environment performed as well as both sham-injured groups. The improved performance of injured rats recovering in the enriched environment occurred in the absence of environmentally induced alterations in brain weight. These results indicate that exposure to environmental complexity enhances recovery of cognitive function after TBI.