Patient-derived organoid (PDO) platforms to facilitate clinical decision making.
Patient-derived organoid (PDO) platforms to facilitate clinical decision making.
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DOI：
10.1186/s12967-020-02677-2
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发表时间：
2021-01-21
影响因子：
7.4
通讯作者：
Huang W
中科院分区：
文献类型：
--
作者：
Liu L;Yu L;Li Z;Li W;Huang W
基于类器官研究的最新进展以及在癌症研究中寻找更准确的药物筛选模型的需求，患者来源的类器官已成为研究癌症的有效体外模型系统。与2D细胞系、3D细胞系和原代细胞培养相比，类器官显示出许多优势，已被应用于药物筛选，以证明基因突变与靶向治疗敏感性之间的相关性。类器官也已用于联合临床试验，以比较类器官中的药物反应与相应患者的临床反应。许多研究已经报道了类器官的成功使用来预测癌症患者的治疗反应。最近，类器官已被用于预测对放疗和免疫疗法的治疗反应。高通量药物筛选和类器官芯片技术的发展可以促进患者来源的类器官在临床实践中的使用，并促进治疗决策。
Based on recent advances in organoid research as well as the need to find more accurate models for drug screening in cancer research, patient-derived organoids have emerged as an effective in vitro model system to study cancer. Showing numerous advantages over 2D cell lines, 3D cell lines, and primary cell culture, organoids have been applied in drug screening to demonstrate the correlation between genetic mutations and sensitivity to targeted therapy. Organoids have also been used in co-clinical trials to compare drug responses in organoids to clinical responses in the corresponding patients. Numerous studies have reported the successful use of organoids to predict therapy response in cancer patients. Recently, organoids have been adopted to predict treatment response to radiotherapy and immunotherapy. The development of high throughput drug screening and organoids-on-a-chip technology can advance the use of patient-derived organoids in clinical practice and facilitate therapeutic decision-making.
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影响因子：
28.2
作者：
Driehuis, Else;Kolders, Sigrid;Clevers, Hans
通讯作者：
Clevers, Hans
影响因子：
14.8
作者：
Cattaneo CM;Dijkstra KK;Fanchi LF;Kelderman S;Kaing S;van Rooij N;van den Brink S;Schumacher TN;Voest EE
通讯作者：
Voest EE
影响因子：
9.9
作者：
Jabs J;Zickgraf FM;Park J;Wagner S;Jiang X;Jechow K;Kleinheinz K;Toprak UH;Schneider MA;Meister M;Spaich S;Sütterlin M;Schlesner M;Trumpp A;Sprick M;Eils R;Conrad C
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Conrad C
影响因子：
64.5
作者：
Gao D;Vela I;Sboner A;Iaquinta PJ;Karthaus WR;Gopalan A;Dowling C;Wanjala JN;Undvall EA;Arora VK;Wongvipat J;Kossai M;Ramazanoglu S;Barboza LP;Di W;Cao Z;Zhang QF;Sirota I;Ran L;MacDonald TY;Beltran H;Mosquera JM;Touijer KA;Scardino PT;Laudone VP;Curtis KR;Rathkopf DE;Morris MJ;Danila DC;Slovin SF;Solomon SB;Eastham JA;Chi P;Carver B;Rubin MA;Scher HI;Clevers H;Sawyers CL;Chen Y
通讯作者：
Chen Y
影响因子：
23.9
作者：
Czerniecki SM;Cruz NM;Harder JL;Menon R;Annis J;Otto EA;Gulieva RE;Islas LV;Kim YK;Tran LM;Martins TJ;Pippin JW;Fu H;Kretzler M;Shankland SJ;Himmelfarb J;Moon RT;Paragas N;Freedman BS
通讯作者：
Freedman BS