Comparison of functional thalamic segmentation from seed-based analysis and ICA
Comparison of functional thalamic segmentation from seed-based analysis and ICA
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DOI：
10.1016/j.neuroimage.2015.04.027
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发表时间：
2015-07-01
期刊：
影响因子：
5.7
通讯作者：
Bagshaw, Andrew P.
中科院分区：
文献类型：
--
作者：
Hale, Joanne R.;Mayhew, Stephen D.;Bagshaw, Andrew P.
丘脑和大脑皮层之间的信息流是适应性大脑功能的关键组成部分，但人类受试者中丘脑 - 皮层相互作用的细节仍不清楚。本研究的主要目的是评估基于种子的连接性分析和独立成分分析（ICA）分别应用于21名健康参与者的静息态功能磁共振成像（fMRI）数据所得到的功能性丘脑网络模式之间的一致性。对于基于种子的分析，通过计算丘脑体素与一组预定义的皮层区域之间的功能连接性（FC）来实现丘脑的功能性分区。受丘脑约束的ICA提供了一种替代的分区方法。两种FC分析都展示出合理且可比的群体水平的丘脑细分，与先前的研究一致。对FC丘脑分割之间空间重叠的定量评估，以及将每种分割与组织学“金标准”丘脑图谱和结构定义的丘脑图谱进行比较，凸显了它们之间的差异，最显著的是与组织学和结构结果的差异。虽然对丘脑 - 皮层连接性的更深入理解依赖于识别多种非侵入性神经成像技术（例如FC、结构连接性和个体特异性核的解剖定位）共有的特征，但这项工作进一步阐明了丘脑的功能组织以及互补分析解决该问题的不同敏感性。（C）2015爱思唯尔公司。保留所有权利。
Information flow between the thalamus and cerebral cortex is a crucial component of adaptive brain function, but the details of thalamocortical interactions in human subjects remain unclear. The principal aim of this study was to evaluate the agreement between functional thalamic network patterns, derived using seed-based connectivity analysis and independent component analysis (ICA) applied separately to resting state functional MRI (fMRI) data from 21 healthy participants. For the seed-based analysis, functional thalamic parcellation was achieved by computing functional connectivity (FC) between thalamic voxels and a set of pre-defined cortical regions. Thalamus-constrained ICA provided an alternative parcellation. Both FC analyses demonstrated plausible and comparable group-level thalamic subdivisions, in agreement with previous work. Quantitative assessment of the spatial overlap between FC thalamic segmentations, and comparison of each to a histological "gold-standard" thalamic atlas and a structurally-defined thalamic atlas, highlighted variations between them and, most notably, differences with both histological and structural results. Whilst deeper understanding of thalamocortical connectivity rests upon identification of features common to multiple non-invasive neuroimaging techniques (e.g. FC, structural connectivity and anatomical localisation of individual-specific nuclei), this work sheds further light on the functional organisation of the thalamus and the varying sensitivities of complementary analyses to resolve it. (C) 2015 Elsevier Inc. All rights reserved.