Observations of subchondral plate advancement during osteochondral repair: a histomorphometric and mechanical study in the rabbit femoral condyle
Observations of subchondral plate advancement during osteochondral repair: a histomorphometric and mechanical study in the rabbit femoral condyle
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DOI：
10.1016/s1063-4584(03)00164-x
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发表时间：
2003-11-01
影响因子：
7
通讯作者：
Heatley, FW
中科院分区：
文献类型：
--
作者：
Qiu, YS;Shahgaldi, BF;Heatley, FW
目的：软骨下板及其重建一直是关节软骨修复的一个研究不足的方面。软骨下板通过自然愈合恢复的程度仍然存在争议。本研究的目的是量化的进步，在修复的骨软骨缺损的软骨下骨，并检查软骨下骨的高度对关节面repair.Design的质量的影响：骨软骨缺损，3毫米直径3毫米深，通过控制钻33只兔子的股骨髁的关节面到软骨下骨。在术后8、16和32周（分别为n=14、12和7）检查修复反应。使用图像分析系统对标本进行力学测试、X线检查、组织学和组织形态计量学检查。结果：8周时，修复性软骨下骨的水平比自然潮标低0.79+/-0.36mm。到16周时，重建的软骨下板不规则，显示76.5%的板延伸超过自然潮标（0.13+/-0.05 mm），而16.9%的板仍低于（0.19+/-0.15 mm）。修复后表面非骨层厚度明显小于邻近软骨（0.23 ± 0.08vs0.38 ± 0.11mm，P
Objective: The subchondral plate and its reconstitution has been an under-researched aspect of articular cartilage repair. The extent to which the subchondral plate is restored by natural healing remains controversial. This study aimed to quantify advancement of subchondral bone during repair of an osteochondral defect, and to examine the effect of subchondral bone height on the quality of articular surface repair.Design: Osteochondral defects, 3 mm diameter by 3 mm deep, were made by controlled drilling through the articular surface into the subchondral bone in femoral condyles of 33 rabbits. The repair response was examined at 8, 16 and 32 weeks (n=14, 12 and 7, respectively) post surgery. The specimens were subjected to mechanical testing, radiography, histology and histomorphometrology using an image analysis system.Results: At 8 weeks, the level of reparative subchondral bone was 0.79+/-0.36 mm below the native tidemark. By 16 weeks, reformed subchondral plate was irregular, showing that 76.5% of the plate had extended beyond the native tidemark (0.13+/-0.05 mm) whilst 16.9% of the plate remained below (0.19+/-0.15 mm). The repaired surface non-osseous layer became thinner than the adjacent cartilage (0.23+/-0.08 vs 0.38+/-0.11 mm, P