Human migration activities drive the fluctuation of ARGs: Case study of landfills in Nanjing, eastern China
Human migration activities drive the fluctuation of ARGs: Case study of landfills in Nanjing, eastern China
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人类迁移活动驱动ARGs波动：以中国东部南京垃圾填埋场为例
DOI：
10.1016/j.jhazmat.2016.04.077
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发表时间：
2016
影响因子：
13.6
通讯作者：
Jiang Xin
中科院分区：
文献类型：
--
作者：
Sun Mingming;Ye Mao;Schwab Arthur P.;Li Xu;Wan Jinzhong;Wei Zhong;Wu Jun;Friman Ville-Petri;Liu Kuan;Tian Da;Liu Manqiang;Li Huixin;Hu Feng;Jiang Xin
垃圾填埋场作为城市垃圾的最终归宿，是研究人类迁移对抗生素耐药性基因波动影响的理想场所。例如，假日期间的大规模人类迁移往往伴随着对ARG丰度有潜在影响的废物倾倒的变化。选择南京3个垃圾填埋场，对15个ARGs和int1基因的丰度变化进行了为期14个月的检测。人类大规模迁移、倾倒废物的数量和温度对垃圾填埋场ARG水平的两月波动影响最为显著。作为中国一个中等规模的国际大都市，数以百万计的大学生和工人在节假日期间迁徙，这导致了废物产生的急剧增加和ARG丰度的波动。与此相一致的是，大规模移民解释了废物倾倒的大部分变化。废弃物倾倒还影响了混合复合污染物的生物可及性，进而对ARGs水平产生积极影响。各种生物可及化合物对ARG丰度的影响顺序为：抗生素b>营养物质b>金属b>有机污染物。与总化合物浓度相比，生物可及化合物浓度与ARG水平的相关性更强。因此，改进废物分类和管理战略有助于减少生物可及污染物的数量，从而更有效地控制城市ARG的传播。
Landfills are perfect sites to study the effect of human migration on fluctuation of antibiotic resistance genes (ARGs) as they are the final destination of municipal waste. For example, large-scale human migration during the holidays is often accompanied by changes in waste dumping having potential effects on ARG abundance. Three landfills were selected to examine fluctuation in the abundance of fifteen ARGs andIntl1 genes for 14 months in Nanjing, eastern China. Mass human migration, the amount of dumped waste and temperature exerted the most significant effects on bimonthly fluctuations of ARG levels in landfill sites. As a middle-sized cosmopolitan city in China, millions of college students and workers migrate during holidays, contributing to the dramatic increases in waste production and fluctuation in ARG abundances. In line with this, mass migration explained most of the variation in waste dumping. The waste dumping also affected the bioaccessibility of mixed-compound pollutants that further positively impacted the level of ARGs. The influence of various bioaccessible compounds on ARG abundance followed the order: antibiotics > nutrients > metals > organic pollutants. Concentrations of bioaccessible compounds were more strongly correlated with ARG levels compared to total compound concentrations. Improved waste classification and management strategies could thus help to decrease the amount of bioaccessible pollutants leading to more effective control for urban ARG dissemination.