A comparison of the effects of prostaglandins E2 and I2 on renal function and renin release in salt-loaded and salt-depleted anaesthetized dogs.
A comparison of the effects of prostaglandins E2 and I2 on renal function and renin release in salt-loaded and salt-depleted anaesthetized dogs.
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比较前列腺素 E2 和 I2 对高盐和低盐麻醉犬肾功能和肾素释放的影响。
DOI：
10.1113/expphysiol.1981.sp002524
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发表时间：
1981
影响因子：
--
通讯作者：
A. Ungar
中科院分区：
文献类型：
--
作者：
R. L. Jones;M. Watson;A. Ungar
将前列腺素E2 （PGE2）和前列腺素I2 （PGI2）输注于钠负荷犬和钠衰竭犬的肾动脉。输注PGI2 （1200 ng/min）可降低钠负荷犬的体压，提高动脉血浆肾素浓度。两种化合物都增加了肾血流量，但PGE2在增加尿流量和钠排泄方面的作用比PGI2强得多。PGI2（300、1200 ng/min）和PGE2 （300 ng/min）可显著降低钠衰竭犬的体压，提高动脉血浆肾素浓度。这两种化合物都刺激尿流量和肾血流量，但PGE2诱导的钠排泄增加比PGI2大得多。PGI2通过诱导血管舒张作用于肾功能，而PGE2也直接作用于肾小管功能。
Prostaglandin E2 (PGE2) and prostaglandins I2 (PGI2) were infused into the renal artery of either sodium-loaded or sodium-depleted dogs. Systemic blood pressure was decreased and arterial plasma renin concentration increased in the sodium-loaded dogs by infusion of PGI2 (1200 ng/min). Both compounds increased renal blood flow but PGE2 had a much more potent effect than PGI2 on increasing urine flow and sodium excretion. In the sodium-depleted dogs systemic blood pressure was significantly decreased and arterial plasma renin concentration increased by infusions of PGI2 (300 and 1200 ng/min) and PGE2 (300 ng/min). Both compounds stimulated urine flow and renal blood flow but PGE2 induced a much larger increase in sodium excretion than PGI2. PGI2 exerts its actions on renal function by inducing vasodilatation whereas PGE2 also has a direct action on tubular function.