ROLE OF THE VENOUS VALVE IN LATE SEGMENTAL OCCLUSION OF VEIN GRAFTS
ROLE OF THE VENOUS VALVE IN LATE SEGMENTAL OCCLUSION OF VEIN GRAFTS
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DOI：
10.1016/0022-4804(79)90032-5
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发表时间：
1979-01-01
影响因子：
2.2
通讯作者：
NOLAN, SP
中科院分区：
文献类型：
--
作者：
BOSHER, LP;DECK, JD;NOLAN, SP
人和动物的晚期节段性静脉移植闭塞 [LSVGO] 可能是由于静脉瓣膜纤维化所致。将一段包含至少 1 个瓣膜的颈静脉翻转并自体移植到 17 只狗的颈动脉上（25 条静脉移植物）。经过不同时间长度后，取出移植物并通过光学显微镜进行研究。 2周后在所有移植物中均观察到内皮下增殖。在 25 个移植物中，有 8 个瓣膜小叶被破坏，而在其他移植物中，瓣膜小叶薄、柔韧且可移动。在 25 个移植物中的 4 个中，瓣膜远端出现隔膜样结构，并堵塞了 20-40% 的血管腔。瓣膜纤维化可能不是 LSVGO 的病因，但正常的瓣叶可能有助于隔膜样结构的形成。选择无瓣静脉段或移植段瓣膜切除术可能会减少 LSVGO 的发生。
Late segmental vein graft occlusion [LSVGO] in man and animals may be due to fibrosed venous valves. A segment of jugular vein containing at least 1 valve was reversed and autogenously grafted to the carotid artery in 17 dogs (25 vein grafts). After various lengths of time the grafts were removed and studied by light microscopy. Subendothelial proliferation was seen in all grafts after 2 wk. In 8 of the 25 grafts valve leaflets were destroyed and in the other grafts the valve leaflets were thin, pliable and mobile. In 4 of the 25 grafts a diaphragm-like structure developed distal to the valve and occluded 20-40% of the vessel lumen. Valvular fibrosis may not be the etiology of LSVGO but the normal valve leaflet may contribute to the formation of a diaphragm-like structure. Selection of valveless venous segments or valvulectomy of graft sections may reduce the occurrence of LSVGO.