CHEMICAL CONTROL OF RESPIRATORY FREQUENCY AND TIDAL VOLUME DURING SLEEP IN PRETERM INFANTS
CHEMICAL CONTROL OF RESPIRATORY FREQUENCY AND TIDAL VOLUME DURING SLEEP IN PRETERM INFANTS
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DOI：
10.1016/0034-5687(80)90027-4
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
CATES, D
中科院分区：
文献类型：
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作者：
RIGATTO, H;KALAPESI, Z;CATES, D
在给定的睡眠状态下，呼吸从周期性变为规律性，反之亦然。由于这种自发的变化在脑电、眼电(EOG)、心电图或身体运动没有变化的情况下发生，它们可能是由二氧化碳等化学刺激引起的。为了验证这一假设，12名早产儿被允许在相同的睡眠状态下发生呼吸模式的自发变化，以及吸入0.3%至1.2%二氧化碳导致这种变化的早产儿被检查。用鼻塞和屏幕流量计测量呼吸模式、呼气率、频率、潮气通气率、吸气时间、呼气时间、总时间、呼吸频率和二氧化碳分压。在快速眼动睡眠中，睡眠从周期性到规律性的自发变化与平均VE从0.466上升到0.530 L/分钟有关，二氧化碳诱导的变化伴随着.ovrhdo.VE从0.416上升到0.571 L/分钟(P<；0.05)。在N[非]-REM睡眠中，VE从0.385上升到0.445 L/分钟(P<0.05)，从0.420上升到0.454 L/分钟(P<0.05)。自发或二氧化碳吸入产生的VE增加与VT减少、Ttot减少、VT/TI减少和PACO2轻度增加有关。显然，在相同的睡眠状态下发生的呼吸模式变化是由化学物质介导的。
During a given sleep state respiration changes from periodic to regular and vice-versa. Because such spontaneous changes occur without changes in EEG, electrooculogram (EOG), ECG or body movements, they may be induced by chemical stimuli such as CO2. To test this hypothesis, 12 preterm infants in whom spontaneous changes in respiratory pattern were allowed to occur within the same sleep state and infants in whom such changes were induced by inhalation of 0.3% to 1.2% CO2 were examined. Using a nosepiece and a screen flowmeter the respiratory pattern, .ovrhdot.VE [expiration rate], f [frequency], .ovrhdot.VT [tidal ventilation rate], TI [inspiratory time], TE [expiratory time], Ttot [total time], .ovrhdot.VT/TI, TI/Ttot and PACO2 [arterial CO2 pressure] was measured. In REM [rapid eye movement] sleep spontaneous changes from periodic to regular were associated with increase in .ovrhdot.VE from 0.466 (mean) to 0.530 l/min (P < 0.5) and CO2 induced changes accompanied by an increase in .ovrhdot.VE from 0.416 to 0.571 l/min (P < 0.05). In N[non]-REM sleep .ovrhdot.VE increased from 0.385 to 0.445 l/min (P < 0.05) during CO2 induced changes, and from 0.420 to 0.454 l/min (P < 0.05) during CO2 induced changes. Increased .ovrhdot.VE produced spontaneously or by CO2 administration was associated with decreased .ovrhdot.VT, decreased Ttot, decreased .ovrhdot.VT/TI and slight increase in PAco2. Apparently respiratory pattern changes occurring within the same sleep state are chemically mediated.