THERMOREGULATION DURING FEVER - CHANGE OF SET-POINT OR CHANGE OF GAIN
THERMOREGULATION DURING FEVER - CHANGE OF SET-POINT OR CHANGE OF GAIN
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DOI：
10.1007/bf00588644
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发表时间：
1970-01-01
影响因子：
4.5
通讯作者：
ATKINS, AR
中科院分区：
文献类型：
--
作者：
MITCHELL, D;SNELLEN, JW;ATKINS, AR
发热期间的体温调节通常是根据控制系统中参考信号电平的变化来描述的。本文提出了另一种假设，即在发热期间，体温调节控制中心经历热原诱导的敏感度或增益的变化。体温调节神经元的行为有力地支持了这一假设。热的和无热的体温调节可以用一个完全没有参考信号，但对控制中心有相反的冷热刺激的模型来描述。
Thermoregulation during fever is generally described in terms of a change in the level of the reference signal in the control system. This paper presents an alternative postulate, namely that during fever the thermoregulatory control centre undergoes a pyrogen-induced change in sensitivity, or gain. This postulate is supported strongly by the behaviour of thermoregulatory neurones. Febrile and afebrile thermoregulation can be described by means of a model with no reference signal at all, but with opposing warm and cold stimuli to the control centre.