A stochastic model for cancer stem cell origin in metastatic colon cancer.
A stochastic model for cancer stem cell origin in metastatic colon cancer.
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DOI：
10.1158/0008-5472.can-07-5779
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发表时间：
2008-09-01
期刊：
影响因子：
11.2
通讯作者：
Lagasse, Eric
中科院分区：
文献类型：
--
作者：
Odoux, Christine;Fohrer, Helene;Hoppo, Toshitaka;Guzik, Lynda;Stolz, Donna Beer;Lewis, Dale W.;Gollin, Susanne M.;Gamblin, T. Clark;Geller, David A.;Lagasse, Eric
人类癌症已被发现包含可能促使癌症进展至转移的转化干细胞。在此我们报道，转移性结肠癌包含具有干细胞预期的所有关键特性的克隆源性肿瘤细胞，包括自我更新以及分化为成熟结肠细胞的能力。此外，当将这些细胞注射到小鼠体内时，它们引发的肿瘤与人类癌症极为相似。对亲代和克隆源性肿瘤细胞的核型分析显示出许多一致的（克隆性的）以及独特的染色体畸变，这表明癌症干细胞中存在染色体不稳定性。因此，这种癌症起源和转移进展的新模型包含了癌症干细胞的层级模型和随机模型的特征，这是由染色体不稳定性的观察结果所推动的。
Human cancers have been found to include transformed stem cells that may drive cancer progression to metastasis. Here we report that metastatic colon cancer contains clonally derived tumor cells with all of the critical properties expected of stem cells, including self-renewal and to the ability to differentiate into mature colon cells. Additionally, when injected into mice, these cells initiated tumors that closely resemble human cancer. Karyotype analyses of parental and clonally-derived tumor cells expressed many consistent (clonal), along with unique chromosomal aberrations, suggesting the presence of chromosomal instability in the cancer stem cells. Thus, this new model for cancer origin and metastatic progression includes features of both the hierarchical model for cancerous stem cells and the stochastic model, driven by the observation of chromosomal instability.