Effects of Long-Term Home Exercise in Participants With Peripheral Artery Disease.
Effects of Long-Term Home Exercise in Participants With Peripheral Artery Disease.
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DOI：
10.1161/jaha.122.029755
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发表时间：
2023-11-07
影响因子：
5.4
通讯作者：
Liang, Menglu
中科院分区：
文献类型：
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作者：
Gardner, Andrew W.;Montgomery, Polly S.;Wang, Ming;Liang, Menglu
这项随机对照试验比较了患有外周动脉疾病的有症状参与者在接受长期家庭锻炼计划 (HEP)、过渡到长期 HEP 的短期监督运动治疗 (SET) 计划 (SET/HEP) 和对照干预后，峰值步行时间 (PWT) 和运动时间至最低小腿肌肉氧饱和度 (StO2) 的长期变化。在前 3 个月，HEP 组和 SET/HEP 组进行间歇性步行以缓解轻度至中度跛行疼痛，而对照组则进行轻度阻力训练。在接下来的 15 个月中，HEP 组继续他们的锻炼计划，SET/HEP 组从 SET 过渡到 HEP 计划，对照组过渡到仅接受步行建议。 HEP组（408±279米至814±393米，P<0.001）和SET/HEP组（457±288米至818±313米，P<0.001）的PWT从基线到第18个月显着增加。 HEP 组（238±241 秒至 497±485 秒，P<0.05）和 SET/HEP 组（296±289 秒至 620±450 秒，P<0.001）的运动达到最小小腿肌肉 StO2 的时间从基线显着增加。 PWT 和运动时间达到最小小腿肌肉 StO2 的这些变化大于对照组（分别为 P<0.001 和 P<0.01）。此外，运动时间达到最小小腿肌肉 StO2 的变化与两个运动组的 PWT 变化相关（r=0.601，P=0.0015）。长期 HEP 和 SET/HEP 可有效改善有症状的外周动脉疾病参与者的 PWT 和运动时间达到最小小腿肌肉 StO2，并且这些变化彼此相关。网址：https://www.clinicaltrials.gov；唯一标识符：NCT00618670。
This randomized controlled trial compared long‐term changes in peak walking time (PWT) and exercise time‐to‐minimum calf muscle oxygen saturation (StO2) in symptomatic participants with peripheral artery disease following a long‐term home exercise program (HEP), a short‐term supervised exercise therapy (SET) program that transitioned to a long‐term HEP (SET/HEP), and a control intervention. For the first 3 months, HEP and SET/HEP groups performed intermittent walking to mild‐to‐moderate claudication pain, whereas the control group performed light resistance training. For the subsequent 15 months, the HEP group continued their exercise program, the SET/HEP group transitioned from SET to the HEP program, and the control group transitioned to only receive walking advice. PWT increased significantly from baseline to month 18 in the HEP group (408±279 meters to 814±393 meters, P<0.001) and in the SET/HEP group (457±288 meters to 818±313 meters, P<0.001). Exercise time‐to‐minimum calf muscle StO2 increased significantly from baseline to month 18 in the HEP group (238±241 seconds to 497±485 seconds, P<0.05) and in the SET/HEP group (296±289 seconds to 620±450 seconds, P<0.001). These changes in PWT and exercise time‐to‐minimum calf muscle StO2 were greater than in the control group (P<0.001 and P<0.01, respectively). Additionally, the change in exercise time‐to‐minimum calf muscle StO2 was correlated with the change in PWT in both exercise groups combined (r=0.601, P=0.0015). Long‐term HEP and SET/HEP were efficacious in improving PWT and exercise time‐to‐minimum calf muscle StO2 in symptomatic participants with peripheral artery disease, and these changes were correlated with each other. URL: https://www.clinicaltrials.gov; Unique identifier: NCT00618670.