Familial hypobetalipoproteinemia associated with a mutant species of apolipoprotein B (B-46).
Familial hypobetalipoproteinemia associated with a mutant species of apolipoprotein B (B-46).
复制标题
与载脂蛋白 B (B-46) 突变种相关的家族性低 β 脂蛋白血症。
DOI：
10.1056/nejm198906153202407
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Terdiman,JF
中科院分区：
文献类型：
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作者：
Young,SG;Hubl,ST;Chappell,DA;Smith,RS;Claiborne,F;Snyder,SM;Terdiman,JF
载脂蛋白B-100和B-48 -是哺乳动物脂蛋白代谢中的重要蛋白质。1两者是同一结构基因的产物，2在人类中位于2号染色体上。678910由肝脏合成。1是富含甘油三酯的极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）的重要结构蛋白，其富含胆固醇酯。载脂蛋白B-100是人体LDL的唯一蛋白质成分，是细胞识别和摄取LDL的配体。
THE two plasma forms of apolipoprotein B—B-100 and B-48 — are important proteins in mammalian lipoprotein metabolism.1Both are products of the same structural gene,2which in humans is located on chromosome 2.345Apolipoprotein B-100 is a glycoprotein containing 4536 amino acids;678910and it is synthesized by the liver.1It is an important structural protein in very-low-density lipoproteins (VLDL), which are rich in triglycerides, and low-density lipoproteins (LDL), which are rich in cholesteryl esters. Apolipoprotein B-100 is virtually the only protein component of human LDL, and it is the ligand responsible for the recognition and uptake of LDL by cellular . . .