HUMAN GRANULOCYTIC EHRLICHIOSIS IN CONNECTICUT - REPORT OF A FATAL CASE
HUMAN GRANULOCYTIC EHRLICHIOSIS IN CONNECTICUT - REPORT OF A FATAL CASE
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DOI：
10.1093/clinids/21.4.910
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发表时间：
1995-10-01
影响因子：
11.8
通讯作者：
DUMLER, JS
中科院分区：
文献类型：
--
作者：
HARDALO, CJ;QUAGLIARELLO, V;DUMLER, JS
我们报告一例71岁男性粒细胞埃立克体病，他表现为急性发热性疾病，随后发展为多系统器官功能障碍和突发性严重贫血，并伴有血小板减少症，需要重症监护、机械通气、血液透析和输血。诊断怀疑是在外周血涂片检查后的第五天；胞浆内包涵体仅存在于粒细胞中。急性期和恢复期血清的血清学检测结果证实诊断为粒细胞性埃立克体病。我们讨论了这一病例的特点，与已发表的病例报告相似，以及治疗过程和结果。据我们所知，这是第一例记录在案的人类粒细胞性埃立克体病病例，发生在上中西部以外，因为埃立克体种可能与鹿扁虱(Dammini)有关，该病例引起了莱姆病流行地区的临床医生和患者的额外关注。
We report a case of granulocytic ehrlichiosis in a 71-year-old man who presented with an acute febrile illness and subsequently developed multisystem organ dysfunction and sudden severe anemia with thrombocytopenia requiring intensive care, mechanical ventilation, hemodialysis, and transfusions. The diagnosis was suspected on the fifth hospital day after a peripheral blood smear was examined; intracytoplasmic inclusion bodies were present in granulocytes only. Results of serological tests of acute and convalescent sera confirmed the diagnosis of granulocytic ehrlichiosis. We discuss the features of this case that were similar to those of published case reports as well as the course and outcome of treatment. This, to our knowledge, represents the first documented case of human granulocytic ehrlichiosis to occur outside the Upper Midwest, Because of the possible epidemiological association of Ehrlichia species with the deer tick Ixodes scapularis (dammini), this case raises additional concern for clinicians and patients in regions where Lyme disease is endemic.