PROSTAGLANDIN PROFILES IN NERVOUS-TISSUE AND BLOOD-VESSELS OF THE BRAIN OF VARIOUS ANIMALS
PROSTAGLANDIN PROFILES IN NERVOUS-TISSUE AND BLOOD-VESSELS OF THE BRAIN OF VARIOUS ANIMALS
复制标题
DOI：
10.1016/0090-6980(80)90023-4
复制
发表时间：
1980-01-01
影响因子：
2.9
通讯作者：
ANGGARD, E
中科院分区：
文献类型：
--
作者：
ABDELHALIM, MS;LUNDEN, I;ANGGARD, E
内源性形成前列腺素（PG） D2, PGE2, PGF2.alpha。和6-keto-PGF1.alpha。用气相色谱-质谱法测定小鼠、大鼠和家兔大脑匀浆及大鼠脑血管。在所有被测试的物种中，6-酮- pgf1。在脑匀浆中发现，但与其他PG. 6-酮- pgf1 - α相比，它是一个次要成分。是血管中PG含量最高的，其含量是脑组织的40倍。PGD2是大鼠和小鼠大脑中最丰富的PG，但在所分析的血管中低于检测限。这些研究表明PG内过氧化物在神经和血管组织中的代谢差异，显然为进一步研究PG在脑循环和神经元活动中的作用提供了生化基础。
The endogenous formation of prostaglandin (PG) D2, PGE2, PGF2.alpha. and 6-keto-PGF1.alpha. was determined in homogenates of mouse, rat and rabbit brain, and of rat cerebral blood vessels, using gas chromatography mass spectrometry. In all species tested, 6-keto-PGF1.alpha. was identified in the brain homogenates, but was a minor component in relation to other PG. 6-keto-PGF1.alpha. was the most abundant PG in the blood vessels, being present in 40-fold higher levels than in the brain tissue. PGD2 was the most abundant PG in rat and mouse brains, but was below detection limits in the analyzed blood vessels. These studies indicating differential metabolism of PG endoperoxides in nervous and vascular tissue apparently provide a biochemical basis for further studies on the role of PG in brain circulation and neuronal activity.