The ventral premammillary nucleus links metabolic cues and reproduction.
The ventral premammillary nucleus links metabolic cues and reproduction.
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DOI：
10.3389/fendo.2011.00057
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发表时间：
2011-01-01
影响因子：
5.2
通讯作者：
Elias, Carol Fuzeti
中科院分区：
文献类型：
--
作者：
Donato, Jose Jr;Elias, Carol Fuzeti
The amount of body fat and the energy balance are important factors that influence the timing of puberty and the normal reproductive function. Leptin is a key hormone that conveys to the central nervous system information about the individual energy reserve and modulates the hypothalamus-pituitary-gonad (HPG) axis. Recent findings suggest that the ventral premammillary nucleus (PMV) mediates the effects of leptin as a permissive factor for the onset of puberty and the coordinated secretion of luteinizing hormone during conditions of negative energy balance. In this review, we will summarize the existing literature about the potential role played by PMV neurons in the regulation of the HPG axis.
