End-point parameter adjustment on a small desk-top programmable calculator for logit-log analysis of radioimmunoassay data.
End-point parameter adjustment on a small desk-top programmable calculator for logit-log analysis of radioimmunoassay data.
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在小型台式可编程计算器上调整终点参数，用于放射免疫分析数据的对数分析。
作者：
K. Hatch;E. Coles;H. Busey;S. C. Goldman
本文介绍了一种改进的logit-log曲线拟合方法，通过调整放射免疫分析研究中的终点参数，与小型台式可编程计算器一起使用。直接logit-log分析通常是有缺陷的，因为它们对终点参数B 0和NSB（管中实际测量的活性）中的小误差具有高灵敏度。文献提出了调整这些终点参数的技术，但它们需要太多的计算时间和编程空间，无法与桌面可编程计算器一起使用。这里提出的logit-log模型的扩展很容易由可编程计算器处理，并提供了B 0和NSB所需变化的良好估计，以获得更好的拟合。该程序需要1.5分钟在我们的桌面可编程计算器上运行，并导致所有11种放射免疫分析研究的数据分析得到改善。
We describe an improved method of logit-log curve fitting, by adjusting end-point parameters in radioimmunoassay studies, for use with a small desk-top programmable calculator. Straight logit-log analyses are often deficient because of their high sensitivity to small errors in the end-point parametes B0 and NSB (the actual measured activity in the tubes). The literature suggests techniques for adjusting these end-point parameters, but they require too much computing time and programming space to be used with a desk-top programmable calculator. The extension to the logit-log model presented here is easily handled by the programmable calculator and provides a good estimate of the change required in B0 and NSB to obtain a better fit. The program requires 1.5 min to run on our desk-top programmable calculator, and has resulted in improved data analysis for all of the 11 types of radioimmunoassay studied.