Microfluidic in-line dynamic light scattering with a commercial fibre optic system
Microfluidic in-line dynamic light scattering with a commercial fibre optic system
复制标题
使用商用光纤系统进行微流体在线动态光散射
DOI：
10.1039/d3lc00062a
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发表时间：
2023
期刊：
影响因子：
6.1
通讯作者：
Torquato L
中科院分区：
文献类型：
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作者：
Torquato L
我们报告的动态光散射（DLS）在微流体的耦合，使用无接触的光纤系统，使一系列的解决方案，分散液和结构化流体的下流特性。该系统进行了评估和验证模型系统，特别是胶束和（稀）聚合物溶液，和不同半径的胶体分散体（λ 1-100 nm）。一个系统的流动DLS分析的方法被检查作为一个函数的流速（0-16 cm s−1），并考虑到相对贡献的“过境”和“布朗”的条款，使识别区域（i）一个静态近似足够，（ii）的流动DLS框架，以及（iii）发现偏差，直到最终（iv）对流占主导地位。我们调查实际相关的，强大的设置，即毛细管连接到微器件，以及直接测量的玻璃微器件，检查毛细管尺寸的作用和光学对准的挑战。我们的结论与演示的连续流测量的二元表面活性剂/盐溶液，其胶束尺寸随组合物而变化，其特征在于数百个数据点（每105秒）和足够的统计，在几分钟内。
We report the coupling of dynamic light scattering (DLS) in microfluidics, using a contact-free fibre-optic system, enabling the under-flow characterisation of a range of solutions, dispersions, and structured fluids. The system is evaluated and validated with model systems, specifically micellar and (dilute) polymer solutions, and colloidal dispersions of different radii (∼1–100 nm). A systematic method of flow-DLS analysis is examined as a function of flow velocity (0–16 cm s−1), and considerations of the relative contribution of ‘transit’ and ‘Brownian’ terms enable the identification of regions where (i) a quiescent approximation suffices, (ii) the flow-DLS framework holds, as well as (iii) where deviations are found, until eventually (iv) the convection dominates. We investigate practically relevant, robust setups, namely that of a capillary connected to microdevice, as well as direct measurement on a glass microdevice, examining the role of capillary dimensions and challenges of optical alignment. We conclude with a demonstration of a continuous flow measurement of a binary surfactant/salt solution, whose micellar dimensions vary with composition, characterised with hundreds of data points (every ∼5 s) and adequate statistics, within a few minutes.