Grid cells in pre- and parasubiculum
Grid cells in pre- and parasubiculum
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DOI：
10.1038/nn.2602
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发表时间：
2010-08-01
影响因子：
25
通讯作者：
Moser, May-Britt
中科院分区：
文献类型：
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作者：
Boccara, Charlotte N.;Sargolini, Francesca;Moser, May-Britt
同种中心空间是由位于海马-海马旁皮质相互连接的亚区域的功能特化细胞类型的广泛大脑回路绘制的。人们对表达这种多种放电模式所需的神经结构知之甚少。在大鼠中，我们发现其中一种细胞类型，即网格细胞，不仅在首次报道的内侧内嗅皮层（MEC）中丰富，而且在前下托和旁下托中也大量存在。前下托和下下托旁网格细胞的比例与 MEC 深层相当。网格图案的对称性及其与 theta 节律的关系较弱，尤其是在前下托。前和旁状网格细胞与头部方向细胞和边缘细胞混合，如在深层 MEC 层中一样。海马旁皮层结构不同的细分中常见的空间反应细胞池的特征限制了可能产生其独特功能放电表型的机制范围。
Allocentric space is mapped by a widespread brain circuit of functionally specialized cell types located in interconnected subregions of the hippocampal-parahippocampal cortices. Little is known about the neural architectures required to express this variety of firing patterns. In rats, we found that one of the cell types, the grid cell, was abundant not only in medial entorhinal cortex (MEC), where it was first reported, but also in pre- and parasubiculum. The proportion of grid cells in pre- and parasubiculum was comparable to deep layers of MEC. The symmetry of the grid pattern and its relationship to the theta rhythm were weaker, especially in presubiculum. Pre- and parasubicular grid cells intermingled with head-direction cells and border cells, as in deep MEC layers. The characterization of a common pool of space-responsive cells in architecturally diverse subdivisions of parahippocampal cortex constrains the range of mechanisms that might give rise to their unique functional discharge phenotypes.