Role of Purinergic Signaling in Voiding Dysfunction.
Role of Purinergic Signaling in Voiding Dysfunction.
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DOI：
10.1007/s11884-010-0063-6
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发表时间：
2010-08-26
影响因子：
0.4
通讯作者：
Chai, Toby C
中科院分区：
文献类型：
--
作者：
Sun, Yan;Chai, Toby C
嘌呤能信号是一个与三磷酸腺苷与其受体(如P2X和P2Y亚型的嘌呤能受体)结合有关的术语。该通路与间质性膀胱炎/痛性膀胱综合征、脊髓损伤继发神经原性膀胱、下尿路症状、糖尿病和衰老相关的膀胱功能障碍有关。嘌呤能信号发生在多个部位，包括中枢神经系统、周围运动神经和感觉神经、逼尿肌平滑肌和膀胱尿路上皮。未来用于治疗膀胱功能障碍的药物可能能够针对其中一个或多个部位的嘌呤能信号。
Purinergic signaling is a term that relates to adenosine triphosphate binding to its receptor (purinergic receptors such as P2X and P2Y subtypes). This pathway has been implicated in bladder functional disorders related to interstitial cystitis/painful bladder syndrome, neurogenic bladder secondary to spinal cord injury, lower urinary tract symptoms, diabetes, and aging. Purinergic signaling occurs at multiple sites, including the central nervous system, peripheral motor and sensory nerves, detrusor smooth muscle, and bladder urothelium. Future pharmacologic agents to treat bladder functional disorders may be able to target purinergic signaling at one or more of these sites.