Magnetic susceptibility reduction method for magnetically labeled immunoassay
Magnetic susceptibility reduction method for magnetically labeled immunoassay
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DOI：
10.1063/1.2206557
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发表时间：
2006-05-22
影响因子：
4
通讯作者：
Yang, H. C.
中科院分区：
文献类型：
--
作者：
Hong, Chin-Yih;Wu, C. C.;Yang, H. C.
除了合成生物功能化的磁性纳米颗粒用于磁性标记生物分子的目的之外，还开发了一种用于测量标记样品的交流磁化率的系统。当靶向生物分子与具有生物功能化磁性纳米颗粒的磁性流体混合时，部分磁性纳米颗粒由于与靶向生物分子的缔合而聚集以形成簇。由于磁性团簇的形成，测得的交流磁化率降低。建立了混合频率交流磁化率降低与检测生物分子量之间的关系。(c)2006年，美国物理学会。
In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established. (c) 2006 American Institute of Physics.