Plantation work and risk of Parkinson disease in a population-based longitudinal study
Plantation work and risk of Parkinson disease in a population-based longitudinal study
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DOI：
10.1001/archneur.59.11.1787
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发表时间：
2002-11-01
影响因子：
--
通讯作者：
White, LR
中科院分区：
文献类型：
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作者：
Petrovitch, H;Ross, GW;White, LR
内容：帕金森病（PD）的病因尚不清楚，然而，令人信服的证据表明，农药可以选择性地损害实验室动物的多巴胺能系统。在人类的回顾性研究表明，暴露于农业生活方式因素和PD.Objective之间的联系：以确定是否在种植园工作在夏威夷和暴露于农药与PD的风险增加decades later.Design and Setting：前瞻性队列研究的基础上，岛屿的Oakland，夏威夷，30年的后续行动。1965年，在研究登记时，通过问卷调查对种植园的工作年限进行了评估。自我报告的农药暴露的信息收集在一个单独的examination 6 years later.Participants：参与者是7986日裔美国人之间出生的1900年和1919年谁被登记在纵向檀香山心脏Program.Main结果Measures：事件PD被确定的医疗记录审查或由一个研究神经学家在稍后的日期进行的检查。结果：在随访期间，116名男性发展为PD。在种植园工作10年以上的男性中，经性别调整的发病率显着增加。PD的相对危险度为1.0（95%置信区间，0.6-1.6），1.7（95%置信区间，0.8-3.7）和1.9（95%置信区间，1.0-3.5）在种植园工作1 - 10年，11 - 20年和超过20年的男性与从未从事种植园工作的男性相比（P= 0.006，趋势检验）。PD的发病率较高的男性暴露于农药比男性没有暴露于农药，虽然这是没有统计学意义（P= 0.10，测试趋势）。结论：这些纵向观察种植园工作在夏威夷支持病例对照研究表明，暴露于农药增加PD的风险。
Context: Parkinson disease (PD) has an unknown cause; however, convincing evidence is emerging that indicates pesticides can selectively injure the dopaminergic system in laboratory animals. Retrospective studies in humans demonstrate a link between exposure to agricultural lifestyle factors and PD.Objective: To determine whether working on a plantation in Hawaii and exposure to pesticides are associated with an increased risk of PD decades later.Design and Setting: Prospective cohort study based on the island of Oahu, Hawaii, with 30 years of follow-up. Years of work on a plantation were assessed by questionnaire at study enrollment in 1965. Self-reported information on pesticide exposure was collected at a separate examination 6 years later.Participants: Participants were 7986 Japanese American men born between 1900 and 1919 who were enrolled in the longitudinal Honolulu Heart Program.Main Outcome Measures: Incident PD was determined by medical record review or by an examination conducted by a study neurologist at a later date..Results: During follow-up, 116 men developed PD. Age-adjusted incidence increased significantly among men who worked more than 10 years on a plantation. The relative risk of PD was 1.0 (95% confidence interval, 0.6-1.6), 1.7 (95% confidence interval, 0.8-3.7), and 1.9 (95% confidence interval, 1.0-3.5) for men who worked on a plantation 1 to 10 years, 11 to 20 years, and more than 20 years compared with men who never did plantation work (P=.006, test for trend). Age-adjusted incidence of PD was higher in men exposed to pesticides than in men not exposed to pesticides although this was not statistically significant (P=.10, test for trend).Conclusion: These longitudinal observations regarding plantation work in Hawaii support case-control studies suggesting that exposure to pesticides increases the risk of PD.