Memory enhancement by central administration of norepinephrine
Memory enhancement by central administration of norepinephrine
复制标题
通过去甲肾上腺素的中枢给药增强记忆
DOI：
10.1016/0006-8993(75)90989-0
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发表时间：
1975
期刊：
影响因子：
2.9
通讯作者：
C. Wise
中科院分区：
文献类型：
--
作者：
L. Stein;J. Belluzzi;C. Wise
在训练试验后立即在105只雄性白化病Charles River大鼠的侧脑室注射单剂量去甲肾上腺素（NE），试图促进被动回避反应的巩固。一组用二乙基二硫代氨基甲酸酯（DDC）预处理，以影响NE耗竭。对照实验中所有实验组均给予NE 10mg脑室注射，并进行复测。结果证实了之前的报道，即被动回避训练期间NE生物合成的抑制可以防止新习得反应的长期（但不是短期）保留，此外，训练后立即给予外源性NE在很大程度上可以恢复长期保留的能力回避反应。由于状态依赖的解释可以被排除，结果支持NE神经元在巩固学习中发挥关键作用的想法。(34参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Attempted to facilitate the consolidation of a passive avoidance response by injection of a single dose of norepinephrine (NE) in the lateral ventricle of the brain in 105 male albino Charles River rats immediately after the training trial. One group of Ss was pretreated with diethyldithiocarbamate (DDC) to affect NE depletion. All experimental groups in the controlled test received a 10mg intraventricular injection of NE and were retested. Results confirm previous reports that inhibition of NE biosynthesis during passive avoidance training prevents long-term (but not short-term) retention of the newly-learned response, and furthermore that immediate posttraining administration of exogenous NE largely reinstates the capacity for long-term retention of the avoidance response. Since state-dependency explanations can be ruled out, results support the idea that NE neurons play a crucial role in the consolidation of learning.(34 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)