Improving Cerebrovascular Function to Increase Neuronal Recovery in Neurodegeneration Associated to Cardiovascular Disease
Improving Cerebrovascular Function to Increase Neuronal Recovery in Neurodegeneration Associated to Cardiovascular Disease
复制标题
DOI：
10.3389/fcell.2020.00053
复制
发表时间：
2020-02
影响因子：
5.5
通讯作者：
Lotte Vanherle;Hana Matušková;Nicholas Don-Doncow;F. Uhl;A. Meissner
中科院分区：
文献类型：
--
作者：
Lotte Vanherle;Hana Matušková;Nicholas Don-Doncow;F. Uhl;A. Meissner
越来越多的证据表明，心血管疾病(CVD)和危险因素的存在会增加认知障碍(CI)和痴呆的发生率。心血管疾病和相关的心血管功能下降可损害脑血流(CBF)调节，导致脑组织氧和营养供应中断，细胞内有限的能量存储能力严重依赖CBF来维持正常的神经元功能。在高血压和急慢性脑血管病期间，脑血流灌注不足和脑血管功能受损往往与神经退行性变有关，并可导致脑梗塞和痴呆。目前，与CVD相关的所有形式的神经退行性变都缺乏有效的治疗方法，这突显了更好地了解脑血管功能障碍和CBF缺陷与神经退行性变之间的具体机制的必要性。在这篇综述中，我们讨论了已经通过改善脑血管功能或CBF缺陷来减轻与高血压、心力衰竭(HF)和中风相关的神经退行性变或CI的血管靶点。
Mounting evidence indicates that the presence of cardiovascular disease (CVD) and risk factors elevates the incidence of cognitive impairment (CI) and dementia. CVD and associated decline in cardiovascular function can impair cerebral blood flow (CBF) regulation, leading to the disruption of oxygen and nutrient supply in the brain where limited intracellular energy storage capacity critically depends on CBF to sustain proper neuronal functioning. During hypertension and acute as well as chronic CVD, cerebral hypoperfusion and impaired cerebrovascular function are often associated with neurodegeneration and can lead to CI and dementia. Currently, all forms of neurodegeneration associated to CVD lack effective treatments, which highlights the need to better understand specific mechanisms linking cerebrovascular dysfunction and CBF deficits to neurodegeneration. In this review, we discuss vascular targets that have already shown attenuation of neurodegeneration or CI associated to hypertension, heart failure (HF) and stroke by improving cerebrovascular function or CBF deficits.