Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer.
Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer.
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DOI：
10.2147/copd.s15417
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发表时间：
2011
影响因子：
2.8
通讯作者：
Dickey BF
中科院分区：
文献类型：
--
作者：
Moghaddam SJ;Ochoa CE;Sethi S;Dickey BF
预计到2020年，慢性阻塞性肺疾病(COPD)将成为世界第三大死亡原因。它的特点是气流受限，不能完全可逆。气流受限通常是进行性的，与肺部对有害颗粒和气体的异常炎症反应有关，最常见的是香烟烟雾。在患有COPD的吸烟者中，即使在戒烟后，炎症仍然存在，肺功能继续恶化。一种可能的解释是，烟雾损伤的呼吸道，最常见的是非分型流感嗜血杆菌(NTHi)的细菌定植，使呼吸道损伤和炎症持续存在。此外，COPD也已被确定为肺癌的独立危险因素，无论伴随的是香烟烟雾暴露。在这篇文章中，我们回顾了NTHi在可能导致COPD进展和肺癌促进的呼吸道炎症中的作用。
Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death in the world by 2020. It is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles and gases, most commonly cigarette smoke. Among smokers with COPD, even following withdrawal of cigarette smoke, inflammation persists and lung function continues to deteriorate. One possible explanation is that bacterial colonization of smoke-damaged airways, most commonly with nontypeable Haemophilus influenzae (NTHi), perpetuates airway injury and inflammation. Furthermore, COPD has also been identified as an independent risk factor for lung cancer irrespective of concomitant cigarette smoke exposure. In this article, we review the role of NTHi in airway inflammation that may lead to COPD progression and lung cancer promotion.