Toxoplasmosis complicating malignancy. Experience at the national cancer institute
Toxoplasmosis complicating malignancy. Experience at the national cancer institute
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弓形体病并发恶性肿瘤。
作者：
W. M. Vietzke;A. Gelderman;P. Grimley;M. Valsamis
国家癌症研究所对6名恶性肿瘤患者进行了严重的、往往是致命的弓形虫感染，这表明弓形虫对中枢神经系统有不同寻常的偏好。文献中还收集了其他14例与恶性肿瘤相关的弓形虫病病例。突出的临床表现是那些类似脑炎或肿块病变的症状。相关的发热、皮疹、心肌炎和肺炎也被描述。主要的病理损害是灰质坏死性脑炎。在几个病例中发生了惊人的DNA病毒感染的巧合。回顾了临床、实验室和病理细节，并讨论了可能的发病机制。值得注意的是，需要提高临床对这种恶性肿瘤的寄生性并发症的认识，因为它可能是可以治疗的。
Severe, often fatal, infection with Toxoplasma gondii, which manifests an unusual predilection for the central nervous system, has been studied in six patients with malignancy at the National Cancer Institute. Fourteen other instances of toxoplasmosis associated with malignancy have been collected from the literature. Prominent clinical findings are those mimicking encephalitis or a mass lesion. Associated fever, rash, myocarditis and pneumonitis are also described. The major pathologic lesion is a necrotizing encephalitis of the gray matter. A striking coincidence of DNA virus infection occurred in several cases. Clinical, laboratory and pathologic details are reviewed and possible pathogenetic mechanisms are discussed. Attention is drawn to the need for increased clinical awareness of this parasitic complication of malignancy, as it may be treatable.