Multigenerational Cardiometabolic Risk as a Predictor of Birth Outcomes: The Bogalusa Heart Study.
Multigenerational Cardiometabolic Risk as a Predictor of Birth Outcomes: The Bogalusa Heart Study.
复制标题
多代心脏代谢风险作为出生结果的预测因子：Bogalusa 心脏研究。
DOI：
10.1016/j.jpeds.2016.10.031
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Bazzano,LydiaA
中科院分区：
文献类型：
--
作者：
Harville,EmilyW;Jacobs,MarniB;Qi,Lu;Chen,Wei;Bazzano,LydiaA
目的探讨第1代(孙辈)心脏代谢危险因素与第3代(孙辈)出生体重和胎龄的关系。研究设计在1973年至今的Bogalusa心脏研究中，母女对与其子女的出生证明相关联；妇女也被问及她们的生育史，建立了包括177代(祖母)、210代(母亲)和424代(子女)的3代连锁。结果孕前心脏代谢危险因素(体重指数、血脂、血糖)或第1代(平均年龄16.2岁)和第2代(平均年龄11.1岁)是第3代出生体重和胎龄的预测因素。结果第2代高BMI与第3代出生体重(每单位28 g，95%可信区间12~44)和胎龄(0.08周，95%CI 0.02~0.14)相关，第1代较高体重指数与较高出生体重(52 g，第一代S高糖水平与第三代出生体重(调整后β111 g，95%CI 33-189)相关，甘油三酯(调整后β−21，95%CI−43-0)和低密度脂蛋白(调整后β−24，95%CI−48-0)与低出生体重相关。结论这些结果提示多代发育规划出生结局的可能性，尽管机制(生物或环境)尚不确定。
ObjectiveTo examine the relationship between generation 1 (grandmaternal) cardiometabolic risk factors and generation 3 (grandchild's) birthweight and gestational age.Study DesignMother-daughter pairs in the Bogalusa Heart Study (1973-present) were linked to their children's birth certificates; women were also interviewed about their reproductive histories, creating a 3-generation linkage including 177 generation 1 (grandmothers), 210 generation 2 (mothers), and 424 generation 3 (children). Prepregnancy cardiometabolic risk factors (body mass index [BMI], lipids, glucose) or generation 1 (mean age 16.2 years) and 2 (mean age 11.1 years) were examined as predictors of generation 3 birthweight and gestational age using linear and logistic regression with adjustment for age, race, parity, and other confounders.ResultsGeneration 2 higher BMI was associated with higher birthweight (28 g per 1 unit, 95% CI 12-44) and gestational age (0.08 weeks, 95% CI 0.02-0.14) in generation 3, and generation 1 higher BMI was associated with higher birthweight (52 g, 95% CI 34-70) in the generation 2. Generation 1's higher glucose levels were associated with higher birthweight in generation 3 (adjusted beta 111 g, 95% CI 33-189), and triglycerides (adjusted beta −21, 95% CI −43-0) and low-density lipoprotein (adjusted beta −24, 95% CI −48-0) were associated with lower birthweight.ConclusionsThese results suggest the possibility of multigenerational developmental programming of birth outcomes, although mechanisms (whether biological or environmental) are undetermined.