DIFFERENTIAL IMAGING OF OCULAR DOMINANCE AND ORIENTATION SELECTIVITY IN MONKEY STRIATE CORTEX
DIFFERENTIAL IMAGING OF OCULAR DOMINANCE AND ORIENTATION SELECTIVITY IN MONKEY STRIATE CORTEX
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DOI：
10.1523/jneurosci.12-08-03115.1992
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发表时间：
1992-08-01
影响因子：
5.3
通讯作者：
BLASDEL, GG
中科院分区：
文献类型：
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作者：
BLASDEL, GG
通过比较两只眼睛的反应获得的眼睛优势的不同图像显示了暗带和光带，其中皮质细胞由右眼和左眼主导。这些包括中心的大多数(但不是全部)组织化学染色的细胞色素氧化酶斑点。通过比较对正交取向的反应而获得的取向差异图像，根据2-脱氧葡萄糖(2DG)放射自显影显示了暗带和亮带，这让人想起早先报道的“取向柱”(Hubel等人，1978年)。然而，它们更短也更碎片化，因为它们不包括缺乏定向选择性的区域。尽管这些“带”来自方向选择性区域，但与其他方向的差异图像进行比较后发现，沿其中心的区域偏爱不同的方向。因此，通过比较双眼刺激和单眼刺激获得的方向差分图像，以及通过比较不同方向获得的眼优势差分图像，研究了眼优势与方位之间的相互作用。在这两种情况下，引发的相互作用都是最小的，这表明随后的实验揭示了一种显著的和意想不到的独立性，至少部分原因是在眼睛优势柱的中心和边缘，对一只眼睛最具选择性的区域和对一种方向最具选择性的区域的横向分离。由于这也可以被视为双目和定向选择性之间的横向相关性，它符合从层4c接收输入的层中同时出现的这些属性，并表明这些属性中的每一个都需要另一个。
Differential images of ocular dominance, acquired by comparing responses to the two eyes, reveal dark and light bands where cortical cells are dominated by the right and left eyes. These include most (but not all) histochemically stained cytochrome oxidase blobs in their centers. Differential images of orientation, acquired by comparing responses to orthogonal orientations, reveal dark and light bands that are reminiscent of the "orientation columns" reported earlier, on the basis of 2-deoxyglucose (2DG) autoradiograms (Hubel et al., 1978). However, they are shorter and more fragmented because they do not include regions lacking selectivity for orientation. Even though these "bands" derive from orientation-selective areas, comparisons with differential images of other orientations reveal that regions along their centers prefer different orientations. Hence, the orientation preferences inferred from "bands" in single differential images, or single 2DG autoradiograms, are not necessarily incorrect.Interactions between ocular dominance and orientation were investigated by comparing differential images of orientation obtained with binocular and monocular stimulation, as well as by comparing differential images of ocular dominance obtained with different orientations. In both cases, the elicited interactions were minimal, indicating a remarkable and unexpected independence that subsequent experiments revealed arises, at least in part, from a lateral segregation of regions most selective f or one eye and regions most selective for one orientation, in the centers and edges of ocular dominance columns. Since this can also be viewed as a lateral correlation between binocularity and orientation selectivity, it fits with the simultaneous emergence of these properties in layers receiving input from layer 4c, and suggests that each of these properties requires the other.