Influence of bone mineral density in circulating adipokines among postmenopausal Arab women
Influence of bone mineral density in circulating adipokines among postmenopausal Arab women
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DOI：
10.1016/j.sjbs.2019.10.007
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发表时间：
2020-01-01
影响因子：
4.4
通讯作者：
Al-Daghri, Nasser M.
中科院分区：
文献类型：
--
作者：
Ansari, Mohammed Ghouse Ahmed;Hussain, Syed Danish;Al-Daghri, Nasser M.
骨质疏松症和骨量减少与骨折风险有着重要的联系。流行病学数据显示，脂肪组织对绝经后骨质疏松症的骨生物学的保护作用。目前的研究评估了绝经后妇女选择脂肪因子和骨密度（BMD）之间的关联。共选择了175名沙特绝经后妇女，并根据其BMD（正常和低BMD）进行分类。使用市售测定试剂盒测定选定脂肪因子（脂联素、瘦素、脂蛋白酶）、胰岛素、25（OH）D和RANKI的循环水平。采用双能X线骨密度仪（DXA）测量骨密度。总体上和在低BMD受试者中，脂联素始终显示与BMD显著负相关（总体-0.34，p < 0.01;低BMD组-0.34，p < 0.01）。在多元回归中，脂联素（-0.29 +/- 0.06，p < 0.00）和（-0.08 +/- 0.04，p < 0.05）与总体骨密度呈负显着性，但分层后抵抗素的显着性消失（-0.05 +/-0.04，p < 0.224），而脂联素在低BMD受试者中保持（-0.22 +/-0.07，p < 0.02）。脂蛋白、瘦素和脂质运载蛋白-2没有显示出显著的相关性。本研究的结果显示，只有脂联素表现出显着强的负相关与低BMD，这表明胰岛素敏感性可能会影响骨健康的阿拉伯绝经后妇女。(C)2019作者由Elsevier B. V.代表沙特国王大学出版。
Osteoporosis and osteopenia has a significant link with substantial fracture risk. Epidemiological data revealed a protective role of adipose tissue on bone biology in postmenopausal osteoporosis. The current study assessed the associations between select adipokines and bone mineral density (BMD) in postmenopausal women. A total of 175 Saudi postmenopausal women were selected and categorized based on their BMD (normal & low-BMD). Circulating levels of select adipokines (adiponectin, resistin, leptin, and adipsin), insulin, 25(OH)D and RANKI were determined using commercially available assay kits. BMD was measured by dual-energy X-ray absorptiometry (DXA). Overall and among low-BMD subjects, adiponectin consistently showed a significant inverse association with BMD (overall -0.34, p < 0.01; low BMD group -0.34, p < 0.01). In multiple regression, adiponectin (-0.29 +/- 0.06, p < 0.00) and resistin (-0.08 +/- 0.04, p < 0.05) were inversely significant with BMD overall, but after stratification the significance was lost for resistin (-0.05 +/- 0.04, p < 0.224) whereas adiponectin remained (-0.22 +/- 0.07, p < 0.02) in low-BMD subjects. Adipsin, leptin and lipocalin-2 showed no significant associations. Findings of the present study revealed that only adiponectin showed a significantly strong inverse association with low BMD, suggesting that insulin sensitivity may influence bone health in Arab postmenopausal women. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of King Saud University.