Eosinophilic esophagitis investigated by upper gastrointestinal endoscopy in Japanese patients
Eosinophilic esophagitis investigated by upper gastrointestinal endoscopy in Japanese patients
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DOI：
10.1007/s00535-011-0435-5
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发表时间：
2011-09-01
影响因子：
6.3
通讯作者：
Kinoshita, Yoshikazu
中科院分区：
文献类型：
--
作者：
Fujishiro, Hirofumi;Amano, Yuji;Kinoshita, Yoshikazu
背景在西方国家，嗜酸性粒细胞性食管炎（EE）的患病率正在迅速增加。日本也报告了几个EE病例系列。然而，通过上消化道内镜检查研究的日本患者中EE的患病率尚不清楚。方法2010年7月至12月，在17家机构接受常规上消化道内镜检查的23,346例患者纳入研究。在有症状提示EE的患者中，如言语困难、食物嵌塞和胃灼热，和/或在内镜检查结果提示病理的患者中，收集食管活检样本，并计数鳞状上皮中的嗜酸性粒细胞。4例患者经内镜和组织学诊断为EE，计算EE的患病率为17.1/100，结论上消化道内窥镜检查发现日本患者EE的患病率已被证实。
Background The prevalence of eosinophilic esophagitis (EE) is increasing rapidly in Western countries. Several case series of EE have also been reported in Japan. However, the prevalence of EE in Japanese patients as investigated by upper gastrointestinal endoscopy is unknown. Therefore, we carried out a prospective multicenter study to address this issue.Methods From July to December 2010, 23,346 patients who had undergone routine upper gastrointestinal endoscopy in 17 institutions were enrolled. In patients with symptoms suggesting EE, such as dysphasia, food impaction, and heartburn, and/or in patients in whom endoscopic findings suggested pathology, esophageal biopsy samples were collected, and the numbers of eosinophils in the squamous epithelium were counted.Results During the study period of 6 months, 4 patients were endoscopically and histologically diagnosed with EE. The prevalence of EE was calculated to be 17.1/100,000.Conclusion The prevalence of EE in Japanese patients by upper gastrointestinal endoscopy has now been documented.