Plasma concentrations of Ir-inhibin, inhibin A, inhibin pro-αC, FSH, and estradiol-17β during estrous cycle in mares and their relationship with follicular growth
Plasma concentrations of Ir-inhibin, inhibin A, inhibin pro-αC, FSH, and estradiol-17β during estrous cycle in mares and their relationship with follicular growth
复制标题
DOI：
10.1385/endo:25:1:07
复制
发表时间：
2004-10-01
期刊：
影响因子：
3.7
通讯作者：
Taya, K
中科院分区：
文献类型：
--
作者：
Medan, MS;Nambo, Y;Taya, K
本研究观察了正常发情周期中雌激素受体（IR）-β-雌二醇（E_2）、β-雌二醇（E_2）、β-雌二醇（E_2）、β-雌二醇（E_2）、β-雌二醇（A_2）、α-雌二醇（A_2）A、β-雌二醇（A_2）前体α-C、FSH水平与卵泡发育的关系。7只母猪连续两个正常发情周期。通过经直肠超声检查获得卵泡直径和排卵情况，每天通过颈静脉穿刺采集血液样本进行激素测定。结果表明，垂体素A与FSH呈负相关（r =-0.59，p < 0.0001），表明垂体素A对垂体FSH分泌起负反馈控制作用。在卵泡期，雌二醇-17 β增加，在排卵前2天达到峰值（37.9 +/- 3.8 pg/mL）。EAE-17 β与EAE bin A呈正相关（r = 0.78，p < 0.0001）。高水平的卵泡素A和雌二醇-17 β与排卵前优势卵泡的生长相关，并与FSH呈负相关，表明这两种激素是大的优势卵泡的产物，并负责在发情周期的卵泡期FSH分泌的下降。总之，清楚地证明了在垂体素A和FSH之间的反比关系，表明垂体素A在垂体FSH的负反馈控制中具有关键作用。此外，卵泡素A和雌二醇-17 β的分泌与排卵前优势卵泡的生长有关，并呈正相关。
The relationship among plasma levels of immunoreactive (ir)-inhibin, inhibin A, inhibin pro-alphaC, FSH, estradiol-17beta and follicular growth were investigated during the normal estrous cycle in mares. Seven mares were used for two successive normal estrous cycles. Follicular diameters and ovulation were obtained by transrectal ultrasonography, and blood samples were collected daily by jugular venipuncture for hormonal assay. The results showed that inhibin A was inversely correlated (r = -0.59, p < 0.0001) with FSH indicating its contribution to negative feedback control of FSH secretions from the pituitary gland. Estradiol-17beta increased during the follicular phase reaching a peak (37.9 +/- 3.8 pg/mL) 2 d before ovulation. Estradiol-17beta was positively correlated (r = 0.78, p < 0.0001) with inhibin A. The high levels of inhibin A and estradiol-17beta were associated with the growth of the preovulatory dominant follicle and inversely correlated with FSH suggesting that both hormones are products of the large dominant follicles and were responsible for the decline in FSH secretion during the follicular phase of estrous cycle. In conclusion, an inverse relationship between inhibin A and FSH was clearly demonstrated indicating that inhibin A has a key role in the negative feedback control of FSH from the pituitary gland. in addition, inhibin A and estradiol-17beta secretions were associated with the growth of the preovulatory dominant follicle and were positively correlated.