Significance of lymph node metastases in patients with pancreatic cancer undergoing curative resection
Significance of lymph node metastases in patients with pancreatic cancer undergoing curative resection
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DOI：
10.1016/s0002-9610(96)00237-1
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发表时间：
1996-11-01
影响因子：
3
通讯作者：
Thomas, JH
中科院分区：
文献类型：
--
作者：
Delcore, R;Rodriguez, FJ;Thomas, JH
背景技术背景：最近的报道表明胰腺癌患者切除后生存率提高，然而，淋巴结转移患者的预后仍然不确定，本研究的目的是确定淋巴结转移的存在是否显著改变了胰腺癌患者的生存率。患者和方法：从1970年至1995年，401例胰腺癌，包括327例胰头肿瘤，进行了评估和治疗。手术死亡率为3%，并发症为22%。97例患者术后中位生存期为14个月估计的1年、2年和5年生存率分别为61%、43%和20%，中位生存期为11.5个月淋巴结阳性患者（0 = 56）和24例（范围2 - 87）（范围0 - 293）个月，淋巴结阴性患者（0 = 41; P = 0.0003），10例（10%）患者存活超过5年，其中9例（90%）淋巴结阴性，老年患者（大于或等于70岁）的中位生存期是年轻患者的两倍（24 vs 12个月，P = 0.03），结论：在接受切除术的患者中，56%发现淋巴结转移，胰头切除术可以在所有年龄的患者中进行，手术死亡率低，它为淋巴结转移患者提供了良好的姑息治疗，并鼓励长期-淋巴结阴性患者的长期生存率以及治愈机会。(C)1996年，Excerpta Medica，Inc.
BACKGROUND: Recent reports suggest an improved survival following resection for patients with pancreatic carcinoma, However, the prognosis for patients with lymph nodes metastases remains uncertain, The purpose of this study was to determine if the presence of lymph node metastases significantly alters survival in patients with otherwise potentially curable pancreatic carcinoma.PATIENTS AND METHODS: Between 1970 and 1995, 401 patients with pancreatic adenocarcinoma, including 327 patients with pancreatic head tumors, were evaluated and treated.RESULTS: One hundred (31%) patients underwent pancreatoduodenectomy. Operative mortality was 3% and morbidity was 22%, Median survival for 97 patients discharged from the hospital following resection was 14 months (range 2 to 293), The estimated 1-, 2-, and 5-year survivals were 61%, 43%, and 20%, respectively, Median survival was 11.5 months (range 2 to 87) for patients with positive lymph nodes (0 = 56) and 24 (range 0 to 293) months for patients with negative lymph nodes (0 = 41; P = 0.0003), Ten patients (10%) survived longer than 5 years, and 9 (90%) of them had-negative lymph nodes, Elderly patients (greater than or equal to 70 years) had a median survival twice as long as younger patients (24 versus 12 months, P = 0.03),CONCLUSIONS: Lymph node metastases are found in 56% of patients undergoing resection, Pancreatoduodenectomy can be performed with low operative mortality in patients of all ages, It offers good palliation for patients with lymph nodes metastases and encouraging long-term survival rates as well as a chance for cure in patients with negative lymph nodes. (C) 1996 by Excerpta Medica, Inc.